Monocytes of newly diagnosed juvenile DM1 patients are prone to differentiate into regulatory IL-10+ M2 macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Immunologic Research"
DOI: 10.1007/s12026-019-09072-0
Abstract: Alternatively activated macrophages (M2) exert anti-inflammatory effects and are crucial for keeping balance between protective and destructive cell-mediated immunity in healing phase of inflammation. Two members of the interferon regulatory factors family, IRF5 and IRF4,… read more here.
Keywords: dm1 patients; newly diagnosed; dm1; regulatory macrophages ... See more keywords
Effect of dual-chamber minimal ventricular pacing on paroxysmal atrial fibrillation incidence in myotonic dystrophy type 1 patients: A prospective, randomized, single-blind, crossover study.
Sign Up to like & getrecommendations! Published in 2018 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2018.03.008
Abstract: BACKGROUND Atrial fibrillation (AF) is a common finding in the myotonic dystrophy type 1 (DM1) population. Pacemakers (PMs) may facilitate the diagnosis and management of frequent subclinical asymptomatic AF episodes. OBJECTIVE The purpose of this… read more here.
Keywords: atrial fibrillation; dm1 patients; mvp phase; ventricular pacing ... See more keywords
Prevalence of atrial fibrillation in myotonic dystrophy type 1: A systematic review
Sign Up to like & getrecommendations! Published in 2021 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2021.01.002
Abstract: Cardiac involvement is recorded in about 80% of patients affected by myotonic dystrophy type 1 (DM1). The prevalence of cardiac conduction abnormalities is well described. Data regarding the prevalence of atrial fibrillation (AF) are still… read more here.
Keywords: atrial fibrillation; dm1 patients; dm1; prevalence ... See more keywords
Ado-trastuzumab emtansine (T-DM1) in patients (pts) with HER2 amplified (amp) tumors excluding breast and gastric/gastro-esophageal junction (GEJ) adenocarcinomas: Results from the National Cancer Institute (NCI) Molecular Analysis for Therapy Choice (MATCH) trial.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.100
Abstract: 100Background: The NCI-MATCH is the largest national signal-finding trial incorporating centralized genomic testing to direct pts to molecularly targeted phase 2 treatment arms. HER2 gene amp is ob... read more here.
Keywords: dm1 patients; trial; match; trastuzumab emtansine ... See more keywords
Dysregulation of GSK3β-Target Proteins in Skin Fibroblasts of Myotonic Dystrophy Type 1 (DM1) Patients.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuromuscular diseases"
DOI: 10.3233/jnd-200558
Abstract: Myotonic dystrophy type 1 (DM1) is the most common monogenetic muscular disorder of adulthood. This multisystemic disease is caused by CTG repeat expansion in the 3'-untranslated region of the DM1 protein kinase gene called DMPK.… read more here.
Keywords: type dm1; dm1; dystrophy type; dm1 patients ... See more keywords
Energy Expenditure, Body Composition, and Skeletal Muscle Oxidative Capacity in Patients with Myotonic Dystrophy Type 1.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neuromuscular diseases"
DOI: 10.3233/jnd-230036
Abstract: BACKGROUND Myotonic dystrophy type 1 (DM1) patients are at risk for metabolic abnormalities and commonly experience overweight and obesity. Possibly, weight issues result from lowered resting energy expenditure (EE) and impaired muscle oxidative metabolism. OBJECTIVES… read more here.
Keywords: dm1; muscle oxidative; body composition; dm1 patients ... See more keywords
Transcriptome changes in DM1 patients’ tissues are governed by the RNA interference pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.955753
Abstract: Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by pathogenic expansions of CTG repeats. The expanded repeats are transcribed to long RNA and induce cellular toxicity. Recent studies suggest that the CUG repeats… read more here.
Keywords: disease; pathway; dm1 patients; rna interference ... See more keywords
Choroidal Changes of Long-Term Type 1 Diabetic Patients without Retinopathy
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostics"
DOI: 10.3390/diagnostics10040235
Abstract: The aim of the study is to assess choroidal thickness (CT) and choroidal volume (CV) in 90 type 1 diabetes mellitus (DM1) patients with no diabetic retinopathy (DR) and 60 control eyes using spectral domain… read more here.
Keywords: dm1 patients; dm1; group; changes long ... See more keywords
In Vivo Parieto-Occipital White Matter Metabolism Is Correlated with Visuospatial Deficits in Adult DM1 Patients
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12102305
Abstract: Myotonic dystrophy type 1 (DM1) is a genetic disorder caused by a (CTG) expansion in the DM protein kinase (DMPK) gene, representing the most common adult muscular dystrophy, characterized by a multisystem involvement with predominantly… read more here.
Keywords: matter; matter metabolism; dm1 patients; white matter ... See more keywords