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Published in 2017 at "Cancer Science"
DOI: 10.1111/cas.13253
Abstract: Trastuzumab emtansine (T‐DM1), an antibody–drug conjugate (ADC) consisting of human epidermal growth factor receptor 2 (HER2)‐targeted mAb trastuzumab linked to antimicrotubule agent mertansine (DM1), has been approved for the treatment of HER2‐positive metastatic breast cancer.…
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Keywords:
dm1;
n87 cells;
dm1 resistance;
resistance ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222312809
Abstract: Trastuzumab-emtansine (T-DM1) is a therapeutic agent molecularly targeting human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC), and it is especially effective for MBC with resistance to trastuzumab. Although several reports have described…
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Keywords:
resistance development;
trastuzumab;
breast cancer;
resistance ... See more keywords