Vitamin K protects against 7,12‐dimethylbenz(A)anthracene induced hepatotoxicity in Wistar rats
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.23042
Abstract: Humans are daily exposed to 7,12‐dimethylbenz(a)anthracene (DMBA), a well known polycyclic aromatic hydrocarbons (PAH). This study investigated the role of dietary intake of Vitamin K (VK), a polyphenolic compound, with potential antioxidative properties, against DMBA‐induced… read more here.
Keywords: induced hepatotoxicity; dimethylbenz anthracene; dmba; wistar rats ... See more keywords
Study of small oligomers based on Ru2(DMBA)4 and meta-phenylene diethynylene
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2017.03.011
Abstract: Abstract The reactions between Ru2 (DMBA)4(NO3)2 (DMBA = N,N’-dimethylbenzamidinate) and meta-phenylene diethynylenes bearing 5-ester substituents (-CO2iPr, L1; -CO2Bn, L2) in the presence of Et2NH afforded a series of oligomeric compounds with meta-phenylene diethynylene bridge, namely L-[Ru2 (DMBA)4L]m… read more here.
Keywords: ru2 dmba; meta phenylene; phenylene diethynylene; dmba ... See more keywords
Pre-Exposure to Chronic Unpredictable Stress Suppresses the Chemopreventive Potential of Aloe Vera (Av) Leaf Gel Against 7,12-Dimethylbenz(a)anthracene (DMBA) Induced Carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2018.1560482
Abstract: Abstract The present study evaluates the topical application of aloe vera (Av) leaf gel as a protective natural product against 7,12-dimethylbenz(a)anthracene (DMBA)-induced skin lesions in Swiss albino mice and as an antioxidant for the systemic… read more here.
Keywords: stress; aloe vera; vera leaf; dmba ... See more keywords
Chemopreventive efficacy of stampidine in a murine breast cancer model
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1724961
Abstract: ABSTRACT Background: The purpose of the present study was to examine the chemopreventive effect of stampidine, an aryl phosphate derivative of stavudine, in side by side comparison with the standard anti-breast cancer drug paclitaxel in… read more here.
Keywords: dmba; stampidine; model; breast cancer ... See more keywords
Prevention of DMBA-induced mammary gland tumors in mice by a dual-function inhibitor of JAK3 and EGF receptor tyrosine kinases
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1737014
Abstract: ABSTRACT Objectives: We tested the chemopreventive effect of WHI-P131 in side by side evaluation with the standard anti-breast cancer drug paclitaxel in the well-established 7,12‐dimethylbenz(a)anthracene (DMBA)-induced breast cancer model. Methods: One hundred BALB/cmice were divided… read more here.
Keywords: dmba induced; breast cancer; whi p131; dmba ... See more keywords
High fat diet-induced obesity and gestational DMBA exposure alter folliculogenesis and the proteome of the maternal ovary
Sign Up to like & getrecommendations! Published in 2024 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioae070
Abstract: Abstract Obesity and ovotoxicant exposures impair female reproductive health with greater ovotoxicity reported in obese relative to lean females. The mother and developing fetus are vulnerable to both during gestation. 7,12-dimethylbenz[a]anthracene (DMBA) is released during… read more here.
Keywords: dmba; induced obesity; maternal ovary; dmba exposure ... See more keywords
Anticancer activity of a 1,4-dihydropyridine in DMBA-induced mouse skin tumor model
Sign Up to like & getrecommendations! Published in 2020 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000887
Abstract: Antitumor potential of a 1,4-dihydropyridine derivative (DHP-8) has been successfully studied previously in a number of cancer cell lines including the human melanoma cells, A375. In order to validate its anticancer activity, DMBA induced tumor… read more here.
Keywords: dmba; dihydropyridine; cancer; dmba induced ... See more keywords
Abstract 10: Sclareol induces apoptosis and inhibits notch signaling in hamster oral carcinogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-10
Abstract: The Notch signaling pathway is an evolutionarily conserved cell signaling pathway. It plays a central role in cell fate decisions and differentiation. The bioavailability of sclareol has been widely studied due to its anti-carcinogenic and… read more here.
Keywords: sclareol; dmba; sclareol induces; notch signaling ... See more keywords
Protective Effects of Pelargonidin against DMBA-Induced Mammary Tumorigenesis in BALB/c Mice through Reduced Oxidative Stress and Lipid Anomalies.
Sign Up to like & getrecommendations! Published in 2023 at "Nutrition and cancer"
DOI: 10.2139/ssrn.4139015
Abstract: Among luminal types of breast cancers, ER + breast cancer is the most frequently diagnosed cancer globally. ER + breast cancer is commonly treated with SERM drugs that block ER to prevent ER-mediated cancerous growth. Our previous computational screening… read more here.
Keywords: balb mice; dmba; cancer; dmba induced ... See more keywords
Oral Intragastric DMBA Administration Induces Acute Lymphocytic Leukemia and Other Tumors in Male Wistar Rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Experimental Pharmacology"
DOI: 10.2147/jep.s349047
Abstract: Background Animal models of blood cancer are important tools to study these malignancies and also screen for novel therapeutic agents. Evidence from past research on the carcinogenic properties of 7,12-dimethylbenz[a]-anthracene (DMBA) was provided by a… read more here.
Keywords: leukemia; dmba; oral intragastric; acute lymphocytic ... See more keywords
The Essential Oil of Cymbopogon citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-Induced Breast Cancer in Female Rats
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25143284
Abstract: C. citratus essential oil and carvacrol have shown an antitumor effect on breast tumor cell lines; the main objective of this research was to evaluate the antitumor effect of the essential oil of Cymbopogon citratus… read more here.
Keywords: antitumor effect; breast; dmba; cancer ... See more keywords