Vitamin K protects against 7,12‐dimethylbenz(A)anthracene induced hepatotoxicity in Wistar rats
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.23042
Abstract: Humans are daily exposed to 7,12‐dimethylbenz(a)anthracene (DMBA), a well known polycyclic aromatic hydrocarbons (PAH). This study investigated the role of dietary intake of Vitamin K (VK), a polyphenolic compound, with potential antioxidative properties, against DMBA‐induced… read more here.
Keywords: induced hepatotoxicity; dimethylbenz anthracene; dmba; wistar rats ... See more keywords
Study of small oligomers based on Ru2(DMBA)4 and meta-phenylene diethynylene
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2017.03.011
Abstract: Abstract The reactions between Ru2 (DMBA)4(NO3)2 (DMBA = N,N’-dimethylbenzamidinate) and meta-phenylene diethynylenes bearing 5-ester substituents (-CO2iPr, L1; -CO2Bn, L2) in the presence of Et2NH afforded a series of oligomeric compounds with meta-phenylene diethynylene bridge, namely L-[Ru2 (DMBA)4L]m… read more here.
Keywords: ru2 dmba; meta phenylene; phenylene diethynylene; dmba ... See more keywords
Pre-Exposure to Chronic Unpredictable Stress Suppresses the Chemopreventive Potential of Aloe Vera (Av) Leaf Gel Against 7,12-Dimethylbenz(a)anthracene (DMBA) Induced Carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2018.1560482
Abstract: Abstract The present study evaluates the topical application of aloe vera (Av) leaf gel as a protective natural product against 7,12-dimethylbenz(a)anthracene (DMBA)-induced skin lesions in Swiss albino mice and as an antioxidant for the systemic… read more here.
Keywords: stress; aloe vera; vera leaf; dmba ... See more keywords
Chemopreventive efficacy of stampidine in a murine breast cancer model
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1724961
Abstract: ABSTRACT Background: The purpose of the present study was to examine the chemopreventive effect of stampidine, an aryl phosphate derivative of stavudine, in side by side comparison with the standard anti-breast cancer drug paclitaxel in… read more here.
Keywords: dmba; stampidine; model; breast cancer ... See more keywords
Prevention of DMBA-induced mammary gland tumors in mice by a dual-function inhibitor of JAK3 and EGF receptor tyrosine kinases
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1737014
Abstract: ABSTRACT Objectives: We tested the chemopreventive effect of WHI-P131 in side by side evaluation with the standard anti-breast cancer drug paclitaxel in the well-established 7,12‐dimethylbenz(a)anthracene (DMBA)-induced breast cancer model. Methods: One hundred BALB/cmice were divided… read more here.
Keywords: dmba induced; breast cancer; whi p131; dmba ... See more keywords
Anticancer activity of a 1,4-dihydropyridine in DMBA-induced mouse skin tumor model
Sign Up to like & getrecommendations! Published in 2020 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000887
Abstract: Antitumor potential of a 1,4-dihydropyridine derivative (DHP-8) has been successfully studied previously in a number of cancer cell lines including the human melanoma cells, A375. In order to validate its anticancer activity, DMBA induced tumor… read more here.
Keywords: dmba; dihydropyridine; cancer; dmba induced ... See more keywords
Abstract 10: Sclareol induces apoptosis and inhibits notch signaling in hamster oral carcinogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-10
Abstract: The Notch signaling pathway is an evolutionarily conserved cell signaling pathway. It plays a central role in cell fate decisions and differentiation. The bioavailability of sclareol has been widely studied due to its anti-carcinogenic and… read more here.
Keywords: sclareol; dmba; sclareol induces; notch signaling ... See more keywords
Protective Effects of Pelargonidin against DMBA-Induced Mammary Tumorigenesis in BALB/c Mice through Reduced Oxidative Stress and Lipid Anomalies.
Sign Up to like & getrecommendations! Published in 2023 at "Nutrition and cancer"
DOI: 10.2139/ssrn.4139015
Abstract: Among luminal types of breast cancers, ER + breast cancer is the most frequently diagnosed cancer globally. ER + breast cancer is commonly treated with SERM drugs that block ER to prevent ER-mediated cancerous growth. Our previous computational screening… read more here.
Keywords: balb mice; dmba; cancer; dmba induced ... See more keywords
Oral Intragastric DMBA Administration Induces Acute Lymphocytic Leukemia and Other Tumors in Male Wistar Rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Experimental Pharmacology"
DOI: 10.2147/jep.s349047
Abstract: Background Animal models of blood cancer are important tools to study these malignancies and also screen for novel therapeutic agents. Evidence from past research on the carcinogenic properties of 7,12-dimethylbenz[a]-anthracene (DMBA) was provided by a… read more here.
Keywords: leukemia; dmba; oral intragastric; acute lymphocytic ... See more keywords
The Essential Oil of Cymbopogon citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-Induced Breast Cancer in Female Rats
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25143284
Abstract: C. citratus essential oil and carvacrol have shown an antitumor effect on breast tumor cell lines; the main objective of this research was to evaluate the antitumor effect of the essential oil of Cymbopogon citratus… read more here.
Keywords: antitumor effect; breast; dmba; cancer ... See more keywords
Investigation of the Anticancer Effect of α-Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2(1H)-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030756
Abstract: Breast cancer is a major cause of death in women worldwide. In this study, 60 female rats were classified into 6 groups; negative control, α-aminophosphonates, arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one, DMBA, DMBA & α-aminophosphonates, and DMBA… read more here.
Keywords: aminoquinolin one; aminophosphonates arylidine; dmba; arylidine derivatives ... See more keywords