Advanced MR imaging and 18F-DOPA PET characteristics of H3K27M-mutant and wild-type pediatric diffuse midline gliomas
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04333-4
Abstract: PurposeThe aim of this study was to investigate MRI-derived diffusion weighted imaging (DWI), 1H-MR spectroscopy (1H-MRS) and arterial spin labeling (ASL) perfusion imaging in comparison with 18F-dihydroxyphenylalanine (DOPA) PET with respect to diagnostic evaluation of… read more here.
Keywords: dmg; dopa pet; wild type; mutant wild ... See more keywords
Study of Temperature Effect on Analog/RF and Linearity Performance of Dual Material Gate (DMG) Vertical Super-Thin Body (VSTB) FET
Sign Up to like & getrecommendations! Published in 2020 at "Silicon"
DOI: 10.1007/s12633-020-00561-8
Abstract: This work presents a simulation study of the influence of temperature on the performance of dual material gate (DMG) vertical super-thin body (VSTB) FET. The introduction of DMG causes a drop in the off-state current… read more here.
Keywords: temperature; dmg; analog; dual material ... See more keywords
Recovery of dimethylglyoxime (DMG) from Ni-DMG complexes
Sign Up to like & getrecommendations! Published in 2018 at "Hydrometallurgy"
DOI: 10.1016/j.hydromet.2018.01.014
Abstract: Abstract Dimethylglyoxime (DMG) is an analytical reagent used to precipitate Ni from its aqueous solution. The process is very efficient for Ni recovery in terms of selectivity and completeness but hardly adopted industrially. The reason… read more here.
Keywords: recovery; sulphuric acid; dmg; dimethylglyoxime dmg ... See more keywords
DIPG-50. A NOVEL ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODEL OF RADIATION-INDUCED GLIOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.095
Abstract: Abstract Diffuse midline glioma (DMG) can arise as a primary tumour but also as a consequence of radiation therapy (RT) in survivors of other paediatric brain tumours. Radiation-associated gliomas are molecularly distinct from primary gliomas… read more here.
Keywords: dmg; model; radiation associated; patient derived ... See more keywords
The intrinsic and microenvironmental features of diffuse midline glioma: Implications for the development of effective immunotherapeutic treatment strategies
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac117
Abstract: Abstract Diffuse midline glioma (DMG), including those of the brainstem (diffuse intrinsic pontine glioma), are pediatric tumors of the central nervous system (CNS). Recognized as the most lethal of all childhood cancers, palliative radiotherapy remains… read more here.
Keywords: dmg; diffuse midline; development; midline glioma ... See more keywords
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma
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DOI: 10.1093/neuonc/noac141
Abstract: Abstract Background Diffuse midline gliomas (DMG) are highly invasive brain tumors with rare survival beyond two years past diagnosis and limited understanding of the mechanism behind tumor invasion. Previous reports demonstrate upregulation of the protein… read more here.
Keywords: id1; dmg; prenatal pontine; diffuse midline ... See more keywords
DIPG-16. THE BIG AND SMALL OF PROTEIN POST-TRANSLATIONAL MODIFICATIONS: TARGETING SUMOYLATION AND CITRULLINATION IN DIFFUSE MIDLINE GLIOMA
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DOI: 10.1093/neuonc/noae064.069
Abstract: Abstract BACKGROUND Protein post-translational modifications (PTMs) alter the properties of protein through proteolytic cleavage, or the addition of modifying groups to one or more amino acids. Histones are major targets of PTMs, including through SUMOylation… read more here.
Keywords: sumoylation; dmg; citrullination; protein post ... See more keywords
DIPG-45. TARGETING HYPERACETYLATION IN PEDIATRIC DIFFUSE MIDLINE GLIOMAS USING ONCOLYTIC ADENOVIRUSES
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DOI: 10.1093/neuonc/noae064.098
Abstract: Abstract BACKGROUND H3K27-altered pediatric diffuse midline glioma (DMG) is a highly aggressive type of brain tumor with a 5-year survival rate of less than 2%. Conventional treatments are restricted to palliative radiation therapy. Therefore, effective… read more here.
Keywords: delta rgd; dmg; pediatric diffuse; oncolytic adenoviruses ... See more keywords
DIPG-51. DIFFUSE MIDLINE GLIOMAS HIJACK MYELOID CELL POPULATIONS TO INITIATE AN ANTI-INFLAMMATORY TUMOR IMMUNE MICROENVIRONMENT
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DOI: 10.1093/neuonc/noae064.104
Abstract: Abstract BACKGROUND Diffuse midline gliomas (DMG) are universally fatal pediatric brain tumors, for which no effective treatment exists. These tumors are known for their “cold” non-inflammatory tumor-immune microenvironment (TIME), which is thought to be a… read more here.
Keywords: dmg; cell; tumor; diffuse midline ... See more keywords
DIPG-61. ARGININE DEPRIVATION USING ADI-PEG20 IMPROVES SURVIVAL IN A SYNGENEIC DIFFUSE MIDLINE GLIOMA MOUSE MODEL
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DOI: 10.1093/neuonc/noae064.114
Abstract: Abstract BACKGROUND Diffuse midline glioma (DMG-H3K27) presents a significant challenge in paediatric oncology, with a read more here.
Keywords: oncology; radiation; dmg; peg20 ... See more keywords
DIPG-74. TARGETING TRANSCRIPTIONAL DYSREGULATION IN DMG THROUGH CDK9 AND HDAC INHIBITOR COMBINATION THERAPY
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DOI: 10.1093/neuonc/noae064.127
Abstract: Abstract BACKGROUND With no successful treatment options available, diffuse midline glioma (DMG) are fatal brain tumors with a median survival of ∼12 months. DMG are characterized by transcriptional dysregulation induced by the H3K27M driver mutations.… read more here.
Keywords: transcriptional dysregulation; treatment; combination; dmg ... See more keywords