Advanced MR imaging and 18F-DOPA PET characteristics of H3K27M-mutant and wild-type pediatric diffuse midline gliomas
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04333-4
Abstract: PurposeThe aim of this study was to investigate MRI-derived diffusion weighted imaging (DWI), 1H-MR spectroscopy (1H-MRS) and arterial spin labeling (ASL) perfusion imaging in comparison with 18F-dihydroxyphenylalanine (DOPA) PET with respect to diagnostic evaluation of… read more here.
Keywords: dmg; dopa pet; wild type; mutant wild ... See more keywords
Study of Temperature Effect on Analog/RF and Linearity Performance of Dual Material Gate (DMG) Vertical Super-Thin Body (VSTB) FET
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DOI: 10.1007/s12633-020-00561-8
Abstract: This work presents a simulation study of the influence of temperature on the performance of dual material gate (DMG) vertical super-thin body (VSTB) FET. The introduction of DMG causes a drop in the off-state current… read more here.
Keywords: temperature; dmg; analog; dual material ... See more keywords
Recovery of dimethylglyoxime (DMG) from Ni-DMG complexes
Sign Up to like & getrecommendations! Published in 2018 at "Hydrometallurgy"
DOI: 10.1016/j.hydromet.2018.01.014
Abstract: Abstract Dimethylglyoxime (DMG) is an analytical reagent used to precipitate Ni from its aqueous solution. The process is very efficient for Ni recovery in terms of selectivity and completeness but hardly adopted industrially. The reason… read more here.
Keywords: recovery; sulphuric acid; dmg; dimethylglyoxime dmg ... See more keywords
DIPG-50. A NOVEL ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODEL OF RADIATION-INDUCED GLIOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.095
Abstract: Abstract Diffuse midline glioma (DMG) can arise as a primary tumour but also as a consequence of radiation therapy (RT) in survivors of other paediatric brain tumours. Radiation-associated gliomas are molecularly distinct from primary gliomas… read more here.
Keywords: dmg; model; radiation associated; patient derived ... See more keywords
The intrinsic and microenvironmental features of diffuse midline glioma: Implications for the development of effective immunotherapeutic treatment strategies
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac117
Abstract: Abstract Diffuse midline glioma (DMG), including those of the brainstem (diffuse intrinsic pontine glioma), are pediatric tumors of the central nervous system (CNS). Recognized as the most lethal of all childhood cancers, palliative radiotherapy remains… read more here.
Keywords: dmg; diffuse midline; development; midline glioma ... See more keywords
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma
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DOI: 10.1093/neuonc/noac141
Abstract: Abstract Background Diffuse midline gliomas (DMG) are highly invasive brain tumors with rare survival beyond two years past diagnosis and limited understanding of the mechanism behind tumor invasion. Previous reports demonstrate upregulation of the protein… read more here.
Keywords: id1; dmg; prenatal pontine; diffuse midline ... See more keywords
HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53.
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-oncology"
DOI: 10.1093/neuonc/noz215
Abstract: BACKGROUND Diffuse midline glioma (DMG) is a pediatric malignancy with poor prognosis. Most children die less than one year after diagnosis. Recently, mutations in histone H3 have been identified and are believed to be oncogenic… read more here.
Keywords: glioma; dmg; treatment; ebp50 irsp53 ... See more keywords
Cerebrospinal Fluid Access Devices in Pediatric Diffuse Midline Glioma Patients: Literature Review and Evaluation of Institutional Practices
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgery"
DOI: 10.1093/neuros/nyz310_650
Abstract: Diffuse midline gliomas (DMG) are the number one cause of cancer death in children. H3K27M mutations occur in 80% of DMG, with distinct tumor biology and poorer response to treatment. H3K27M is detectable in cerebrospinal… read more here.
Keywords: diffuse midline; cerebrospinal fluid; access; dmg ... See more keywords
ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-23-0186
Abstract: Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is… read more here.
Keywords: pi3k akt; dmg; diffuse midline; combination ... See more keywords
Abstract 2671: Imipridones ONC201 and ONC206 reduce expression of neogenin and EZH1/2 which correlate with synergy following their combination with EZH1/2 or HDAC inhibitors in treatment of DMG and other tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2671
Abstract: Imipridones are a family of small molecule compounds including ONC201, ONC206 and ONC212 with anti-cancer activity mediated in part through activation of the integrated stress response, induction of TRAIL and its receptor, DR5, and activation… read more here.
Keywords: onc201 onc206; dmg; combination; hdac inhibitors ... See more keywords
Abstract 4304: Network-based inference identifies cell state-specific drugs targeting master regulator vulnerabilities in diffuse midline glioma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4304
Abstract: Diffuse Midline Glioma (DMG) are fatal pediatric brain tumors with no therapies. We leveraged network-based methodologies to dissect the heterogeneity of DMG tumors and to discover Master Regulator (MR) proteins representing pharmacologically accessible, mechanistic determinants… read more here.
Keywords: cell; dmg; network; diffuse midline ... See more keywords