HGG-16. DISSECTING THE EFFECT OF ATM DELETION ON RADIOSENSITIVITY IN DIFFUSE MIDLINE GLIOMAS WITH H3K27M MUTATION
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DOI: 10.1093/neuonc/noab090.082
Abstract: Diffuse midline gliomas (DMGs) are responsible for a large proportion of childhood brain tumor deaths. Currently, radiation therapy is thought to be one of the most effective treatment options, but more than 90% of children… read more here.
Keywords: h3k27m; diffuse midline; dmgs; midline gliomas ... See more keywords
Novel EGFR mutations in diffuse midline gliomas using cost-effective strategies: A report of 2 cases.
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DOI: 10.1093/nop/npae008
Abstract: Background Diffuse midline gliomas (DMGs) are malignant tumors predominantly affecting children, often leading to poor outcomes. The 2021 World Health Organization classification identifies 3 subtypes of DMGs, all characterized by the loss of H3K27 trimethylation.… read more here.
Keywords: dmgs; diffuse midline; report cases; novel egfr ... See more keywords
Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma.
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DOI: 10.1158/0008-5472.can-24-5027
Abstract: Diffuse midline gliomas (DMGs) are devastating brain tumors that occur primarily in children. The salient feature of these tumors is the presence of a H3K27M mutation (K27M), associated with the worst prognosis. Development of effective… read more here.
Keywords: dmgs; anti cd99; diffuse midline; development ... See more keywords