Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.4942
Abstract: Importance Primary resistance to immune checkpoint inhibitors is observed in 10% to 40% of patients with metastatic colorectal cancer (mCRC) displaying microsatellite instability (MSI) or defective mismatch repair (dMMR). Objective To investigate possible mechanisms underlying… read more here.
Keywords: status; immune checkpoint; checkpoint inhibitors; dmmr ... See more keywords
Patients atteints d’un cancer gastrique localisé MSI/dMMR, pas de chimiothérapie mais une immunothérapie périopératoire : l’essai de phase II GERCOR NEONIPIGA vient d’être ouvert au recrutement
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin Du Cancer"
DOI: 10.1016/j.bulcan.2019.11.016
Abstract: Resume Introduction La chimiotherapie perioperatoire est la strategie de reference pour les cancers gastriques (CG) localises, mais semble inefficace voire deletere pour les patients avec un cancer MSI/dMMR (microsatellites instables/MMR-deficient), biomarqueur predictif de l’efficacite de… read more here.
Keywords: pour les; dmmr; gercor neonipiga; msi dmmr ... See more keywords
Response to Chemotherapy and Prognosis in Metastatic Colorectal Cancer With DNA Deficient Mismatch Repair
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Colorectal Cancer"
DOI: 10.1016/j.clcc.2016.11.001
Abstract: Background: DNA deficient mismatch repair (dMMR) genes are associated with microsatellite instability and good prognosis in early‐stage colorectal cancer (CRC). However dMMR is rare in metastatic CRC (mCRC) and little is known about its influence… read more here.
Keywords: chemotherapy; response; dmmr; colorectal cancer ... See more keywords
Immunogenomic landscape of dMMR tumours
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/s41585-018-0095-9
Abstract: Immunogenomic analysis of advanced prostate cancer has identified immunological alterations associated with defective mismatch repair (dMMR) that could inform immunotherapy strategies. Overall, dMMR status was confirmed in 8.1% of patients and was associated with poor… read more here.
Keywords: dmmr; landscape dmmr; immunogenomic landscape; dmmr tumours ... See more keywords
Detecting immunotherapy-sensitive subtype in gastric cancer using histologic image-based deep learning
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02168-4
Abstract: Immune checkpoint inhibitor (ICI) therapy is widely used but effective only in a subset of gastric cancers. Epstein–Barr virus (EBV)-positive and microsatellite instability (MSI) / mismatch repair deficient (dMMR) tumors have been reported to be… read more here.
Keywords: msi; ebv msi; dmmr; deep learning ... See more keywords
Nonoperative Management of dMMR/MSI-H Colorectal Cancer following Neoadjuvant Immunotherapy: A Narrative Review
Sign Up to like & getrecommendations! Published in 2023 at "Clinics in Colon and Rectal Surgery"
DOI: 10.1055/s-0043-1767703
Abstract: Abstract Immunotherapy with PD-1 blockade has achieved a great success in colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch repair (dMMR), and has become the first-line therapy in metastatic setting. Studies of… read more here.
Keywords: narrative review; immunotherapy; neoadjuvant immunotherapy; msi ... See more keywords
Pembrolizumab (pembro) in Mismatch Repair-Deficient (dMMR) Advanced Colorectal Cancer (CRC): KEYNOTE-164 Japan Subgroup
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz339.012
Abstract: Abstract Background Pembro is approved for microsatellite instability-high (MSI-H)/dMMR CRC that has progressed on fluoropyrimidine+oxaliplatin+irinotecan (Fp+Ox+Ir), based in part on data from the ongoing phase 2 KEYNOTE-164 study (NCT02460198). The outcomes of the Japan (Jpn)… read more here.
Keywords: cohorts ajpn; subgroup; dmmr; keynote 164 ... See more keywords
Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16454
Abstract: Abstract Background Microsatellite instability (MSI) is a type of genomic instability caused by mismatch repair deficiency (dMMR) in tumors. Studies on dMMR/MSI are limited, and the relationship between dMMR and MSI is unknown in tumors… read more here.
Keywords: microsatellite instability; relationship; instability; msi ... See more keywords
Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes
Sign Up to like & getrecommendations! Published in 2019 at "Gut"
DOI: 10.1136/gutjnl-2017-315664
Abstract: Objective Tumour-infiltrating lymphocyte (TIL) response and deficient DNA mismatch repair (dMMR) are determinants of prognosis in colorectal cancer. Although highly correlated, evidence suggests that these are independent predictors of outcome. However, the prognostic significance of… read more here.
Keywords: til low; pmmr; dmmr; til mmr ... See more keywords
Extent of investigation and management of cases of ‘unexplained’ mismatch repair deficiency (u-dMMR): a UK Cancer Genetics Group consensus
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Genetics"
DOI: 10.1136/jmg-2024-109886
Abstract: Background Mismatch repair deficiency (dMMR) is a characteristic feature of cancers linked to Lynch syndrome. However, in most cases, it results from sporadic somatic events rather than hereditary factors. The term ‘Lynch-like syndrome’ (LLS) has… read more here.
Keywords: genetics; mismatch repair; cancer; dmmr ... See more keywords
Intertumoral Heterogeneity of CD3+ and CD8+ T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for Prognosis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-1984
Abstract: Purpose: Colorectal cancers with deficient DNA mismatch repair (dMMR) are presumed to uniformly have dense lymphocytic infiltration that underlies their favorable prognosis and is critical to their responsiveness to immunotherapy, as compared with MMR-proficient (pMMR)… read more here.
Keywords: heterogeneity; dmmr; cell densities; pmmr ... See more keywords