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   Articles with "dmmr" as a keyword



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Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status

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recommendations! Published in 2018 at "JAMA Oncology"

DOI: 10.1001/jamaoncol.2018.4942

Abstract: Importance Primary resistance to immune checkpoint inhibitors is observed in 10% to 40% of patients with metastatic colorectal cancer (mCRC) displaying microsatellite instability (MSI) or defective mismatch repair (dMMR). Objective To investigate possible mechanisms underlying… read more here.

Keywords: status; immune checkpoint; checkpoint inhibitors; dmmr ... See more keywords
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Patients atteints d’un cancer gastrique localisé MSI/dMMR, pas de chimiothérapie mais une immunothérapie périopératoire : l’essai de phase II GERCOR NEONIPIGA vient d’être ouvert au recrutement

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recommendations! Published in 2020 at "Bulletin Du Cancer"

DOI: 10.1016/j.bulcan.2019.11.016

Abstract: Resume Introduction La chimiotherapie perioperatoire est la strategie de reference pour les cancers gastriques (CG) localises, mais semble inefficace voire deletere pour les patients avec un cancer MSI/dMMR (microsatellites instables/MMR-deficient), biomarqueur predictif de l’efficacite de… read more here.

Keywords: pour les; dmmr; gercor neonipiga; msi dmmr ... See more keywords
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Response to Chemotherapy and Prognosis in Metastatic Colorectal Cancer With DNA Deficient Mismatch Repair

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recommendations! Published in 2017 at "Clinical Colorectal Cancer"

DOI: 10.1016/j.clcc.2016.11.001

Abstract: Background: DNA deficient mismatch repair (dMMR) genes are associated with microsatellite instability and good prognosis in early‐stage colorectal cancer (CRC). However dMMR is rare in metastatic CRC (mCRC) and little is known about its influence… read more here.

Keywords: chemotherapy; response; dmmr; colorectal cancer ... See more keywords
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Immunogenomic landscape of dMMR tumours

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recommendations! Published in 2018 at "Nature Reviews Urology"

DOI: 10.1038/s41585-018-0095-9

Abstract: Immunogenomic analysis of advanced prostate cancer has identified immunological alterations associated with defective mismatch repair (dMMR) that could inform immunotherapy strategies. Overall, dMMR status was confirmed in 8.1% of patients and was associated with poor… read more here.

Keywords: dmmr; landscape dmmr; immunogenomic landscape; dmmr tumours ... See more keywords
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Detecting immunotherapy-sensitive subtype in gastric cancer using histologic image-based deep learning

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-02168-4

Abstract: Immune checkpoint inhibitor (ICI) therapy is widely used but effective only in a subset of gastric cancers. Epstein–Barr virus (EBV)-positive and microsatellite instability (MSI) / mismatch repair deficient (dMMR) tumors have been reported to be… read more here.

Keywords: msi; ebv msi; dmmr; deep learning ... See more keywords
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Nonoperative Management of dMMR/MSI-H Colorectal Cancer following Neoadjuvant Immunotherapy: A Narrative Review

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recommendations! Published in 2023 at "Clinics in Colon and Rectal Surgery"

DOI: 10.1055/s-0043-1767703

Abstract: Abstract Immunotherapy with PD-1 blockade has achieved a great success in colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch repair (dMMR), and has become the first-line therapy in metastatic setting. Studies of… read more here.

Keywords: narrative review; immunotherapy; neoadjuvant immunotherapy; msi ... See more keywords
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Pembrolizumab (pembro) in Mismatch Repair-Deficient (dMMR) Advanced Colorectal Cancer (CRC): KEYNOTE-164 Japan Subgroup

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recommendations! Published in 2019 at "Annals of Oncology"

DOI: 10.1093/annonc/mdz339.012

Abstract: Abstract Background Pembro is approved for microsatellite instability-high (MSI-H)/dMMR CRC that has progressed on fluoropyrimidine+oxaliplatin+irinotecan (Fp+Ox+Ir), based in part on data from the ongoing phase 2 KEYNOTE-164 study (NCT02460198). The outcomes of the Japan (Jpn)… read more here.

Keywords: cohorts ajpn; subgroup; dmmr; keynote 164 ... See more keywords
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Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs

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recommendations! Published in 2022 at "Journal of Veterinary Internal Medicine"

DOI: 10.1111/jvim.16454

Abstract: Abstract Background Microsatellite instability (MSI) is a type of genomic instability caused by mismatch repair deficiency (dMMR) in tumors. Studies on dMMR/MSI are limited, and the relationship between dMMR and MSI is unknown in tumors… read more here.

Keywords: microsatellite instability; relationship; instability; msi ... See more keywords
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Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes

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recommendations! Published in 2019 at "Gut"

DOI: 10.1136/gutjnl-2017-315664

Abstract: Objective Tumour-infiltrating lymphocyte (TIL) response and deficient DNA mismatch repair (dMMR) are determinants of prognosis in colorectal cancer. Although highly correlated, evidence suggests that these are independent predictors of outcome. However, the prognostic significance of… read more here.

Keywords: til low; pmmr; dmmr; til mmr ... See more keywords
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Intertumoral Heterogeneity of CD3+ and CD8+ T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for Prognosis

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recommendations! Published in 2018 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-18-1984

Abstract: Purpose: Colorectal cancers with deficient DNA mismatch repair (dMMR) are presumed to uniformly have dense lymphocytic infiltration that underlies their favorable prognosis and is critical to their responsiveness to immunotherapy, as compared with MMR-proficient (pMMR)… read more here.

Keywords: heterogeneity; dmmr; cell densities; pmmr ... See more keywords
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Different surgical outcome and follow-up status between dMMR and pMMR colorectal cancer patients who fulfilled with Amsterdam-II criteria

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recommendations! Published in 2020 at "World Journal of Surgical Oncology"

DOI: 10.1186/s12957-020-01976-8

Abstract: Background Although hereditary non-polyposis colorectal cancer (HNPCC) could be subtyped into proficient or deficient mismatch repair gene expression (pMMR or dMMR), distinct clinical features between these two subgroups patients were rarely reported. Methods We retrospectively… read more here.

Keywords: dmmr; colorectal cancer; dmmr pmmr; patients fulfilled ... See more keywords