Microsatellite instability screening in colorectal adenomas to detect Lynch syndrome patients? A systematic review and meta-analysis
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DOI: 10.1038/s41431-019-0538-7
Abstract: The colorectal cancer spectrum has changed due to population screening programs, with a shift toward adenomas and early cancers. Whether it would be a feasible option to test these adenomas for detection of Lynch syndrome… read more here.
Keywords: adenomas; dmmr msi; syndrome patients; lynch syndrome ... See more keywords
Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas.
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DOI: 10.1053/j.gastro.2017.11.009
Abstract: Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is detected in a small proportion of pancreatic ductal adenocarcinomas (PDACs). dMMR and MSI have been associated with responses of metastatic tumors, including PDACs, to immune… read more here.
Keywords: msi; papillary mucinous; pdacs dmmr; dmmr msi ... See more keywords
Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004001
Abstract: Background Despite unprecedented benefit from immune checkpoint inhibitors (ICIs) in patients with mismatch repair deficient (dMMR)/microsatellite instability high (MSI-H) advanced gastrointestinal cancers, a relevant proportion of patients shows primary resistance or short-term disease control. Since… read more here.
Keywords: patients dmmr; immune checkpoint; peritoneal metastases; metastatic colorectal ... See more keywords
Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004703
Abstract: Background Gastrointestinal (GI) cancer is the second most common cancer type with mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) phenotype that is expected to respond to immune-checkpoint inhibitors (ICIs). However, approximately half of the patients with dMMR/MSI-H… read more here.
Keywords: primary resistance; dmmr msi; icis; cancer ... See more keywords
Expanding the Scope of Immunotherapy in Colorectal Cancer: Current Clinical Approaches and Future Directions
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DOI: 10.1155/2020/9037217
Abstract: The success of immune checkpoint inhibitors (ICIs) in an increasing range of heavily mutated tumor types such as melanoma has culminated in their exploration in different subsets of patients with metastatic colorectal cancer (mCRC). As… read more here.
Keywords: scope immunotherapy; subset patients; colorectal cancer; dmmr msi ... See more keywords
Nivolumab Has Antitumor Activity in dMMR/MSI-H Colorectal Cancer.
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DOI: 10.1158/2159-8290.cd-rw2017-141
Abstract: Nivolumab is safe and achieves durable responses in metastatic dMMR/MSI-H colorectal cancer. read more here.
Keywords: cancer; colorectal cancer; msi colorectal; dmmr msi ... See more keywords
Characterization and clinical outcomes of mismatch repair deficient (dMMR) small bowel adenocarcinoma (SBA).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.1511
Abstract: 1511 Background: SBA is a rare cancer known to be associated with Lynch syndrome (LS). The prevalence, tumor characteristics, and clinical course of SBAs in the setting of LS is not well understood. We sought… read more here.
Keywords: mismatch repair; dmmr msi; group; sba ... See more keywords
Prevalence of NTRK1/3 fusions in mismatch repair-deficient (dMMR)/microsatellite instable (MSI) tumors of patients with metastatic colorectal cancer (mCRC).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e15537
Abstract: e15537 Background: Inhibitors of tropomyosin receptor kinase (TRK) have shown promising activity against neurotrophic TRK ( NTRK) fusion-driven cancers, regardless of tumor histotype or cell of origin. NTRK gene fusions are observed in less than… read more here.
Keywords: mismatch repair; fusion; tumor; dmmr msi ... See more keywords
Adjuvant Chemotherapy for Gastric Cancer Patients with Mismatch Repair Deficiency or Microsatellite Instability: Systematic Review and Meta-Analysis
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DOI: 10.1245/s10434-021-11050-6
Abstract: Mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) status serves as a predictor of a poor response to adjuvant chemotherapy among stage 2 colon cancer patients. This study aimed to investigate the efficacy of adjuvant chemotherapy… read more here.
Keywords: chemotherapy; adjuvant chemotherapy; dmmr msi; microsatellite instability ... See more keywords
Case Report and Literature Review: Diagnosis, Tailored Genetic Counseling and Cancer Prevention for a Locally Advanced dMMR/MSI-H/TMB-H Lung Cancer Patient With Concurrent Lynch Syndrome Mediated by a Rare PMS2 Splicing Variant (c.1144+1G>A)
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.799807
Abstract: Lynch syndrome (LS) is a cancer-predisposing genetic disease mediated by pathogenic mutations in DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. Accumulating evidence demonstrates that there is significant biological heterogeneity across MMR genes.… read more here.
Keywords: cancer; lynch syndrome; lung cancer; dmmr msi ... See more keywords
Treatments after Immune Checkpoint Inhibitors in Patients with dMMR/MSI Metastatic Colorectal Cancer
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DOI: 10.3390/cancers14020406
Abstract: Simple Summary Several studies suggested an enhanced efficacy of conventional treatments (CT, i.e., chemotherapy +/− targeted therapy) administered after immune checkpoint inhibitors (ICI) in certain tumor types, but no data are available concerning metastatic colorectal… read more here.
Keywords: metastatic colorectal; dmmr msi; colorectal cancer; mcrc ... See more keywords