Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment
Sign Up to like & getrecommendations! Published in 2017 at "Natural Products and Bioprospecting"
DOI: 10.1007/s13659-017-0125-y
Abstract: The antiparasitic activity and preliminary in vitro and in silico drug metabolism and pharmacokinetic (DMPK) assessment of six isomeric sesquiterpenes (1–6), isolated from the Cameroonian spice Scleria striatinux De Wild (Cyperaceae) is reported. The study… read more here.
Keywords: dmpk; vitro silico; dmpk assessment; assessment ... See more keywords
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development
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DOI: 10.1080/00498254.2022.2124389
Abstract: Abstract As the Space Race or Formula 1 drives innovation, efficiency and progress in home technology and home car markets, Drug Metabolism and Pharmacokinetics (DMPK) drives scientific innovation and value for drug development companies. Stand… read more here.
Keywords: time; core; dmpk; drug development ... See more keywords
AON-induced splice-switching and DMPK pre-mRNA degradation as potential therapeutic approaches for Myotonic Dystrophy type 1
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DOI: 10.1093/nar/gkaa007
Abstract: Abstract Expansion of an unstable CTG repeat in the 3′UTR of the DMPK gene causes Myotonic Dystrophy type 1 (DM1). CUG-expanded DMPK transcripts (CUGexp) sequester Muscleblind-like (MBNL) alternative splicing regulators in ribonuclear inclusions (foci), leading… read more here.
Keywords: dmpk; dystrophy type; chemistry; myotonic dystrophy ... See more keywords