Long term survival in high-risk patients after percutaneous mitral leaflet repair in a single centre: comparable mortality regardless of aetiology
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.2639
Abstract: Percutaneous mitral leaflet repair (PMVR) is a safe and effective alternative to conventional surgery in high-risk patients with both degenerative (DMR) and functional (FMR) mitral regurgitation. We present an analysis of a large cohort of… read more here.
Keywords: high risk; mortality; regardless aetiology; risk patients ... See more keywords
Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse Dlk1-Dio3 domain
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DOI: 10.1093/hmg/ddab071
Abstract: Abstract The Dlk1-Dio3 imprinted domain, regulated by an intergenic differentially methylated region (IG-DMR), is important for mammalian embryonic development. Although previous studies have reported that DNA methylation of a tandem repeated array sequence in paternal… read more here.
Keywords: domain; tandem; dmr; dlk1 dio3 ... See more keywords
Do assisted reproductive technologies and in vitro embryo culture influence the epigenetic control of imprinted genes and transposable elements in children?
Sign Up to like & getrecommendations! Published in 2020 at "Human reproduction"
DOI: 10.1093/humrep/deaa310
Abstract: STUDY QUESTION Do assisted reproductive technologies (ART) and in vitro embryo culture influence the epigenetic control of imprinted genes (IGs) and transposable elements (TEs) in children? SUMMARY ANSWER Significant differences in the DNA methylation of… read more here.
Keywords: methylation; embryo culture; study; epigenetic control ... See more keywords
Degenerative mitral regurgitation.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Cardiology"
DOI: 10.1097/hco.0000000000000769
Abstract: PURPOSE OF REVIEW Degenerative mitral regurgitation (DMR) continues to be an important cause of morbidity and mortality with surgical mitral valve repair remaining the gold standard for the treatment of severe disease. The purpose of… read more here.
Keywords: dmr; regurgitation; degenerative mitral; physiology ... See more keywords
Hypermethylation of delta-like homolog 1/maternally expressed gene 3 loci in human umbilical veins: insights into offspring vascular dysfunction born after preeclampsia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000001942
Abstract: Background: Increasing epidemiological studies have confirmed the association between maternal preeclampsia and elevated blood pressure in their offspring. Though case–control or cohort studies have demonstrated long-term outcomes for the offspring of preeclampsia, it is still… read more here.
Keywords: expression; dmr; dlk1 meg3; preeclampsia ... See more keywords
Improving the Robustness of the Dominant Mode Rejection Beamformer With Median Filtering
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DOI: 10.1109/access.2022.3221954
Abstract: Abraham’s and Owsley’s dominant mode rejection (DMR) beamformer modifies Capon’s minimum variance distortionless response beamformer to force suitable constraints in the covariance matrix estimation process to reduce degrees of freedom. DMR estimates the ensemble covariance… read more here.
Keywords: dominant mode; median dmr; dmr; mode rejection ... See more keywords
Cell type‐specific DNA methylation analysis of the prefrontal cortex of patients with schizophrenia
Sign Up to like & getrecommendations! Published in 2021 at "Psychiatry and Clinical Neurosciences"
DOI: 10.1111/pcn.13282
Abstract: Epigenetics reflects complex interactions between genes and the environment and plays a role in long-lasting gene expression changes. Therefore, unraveling epigenetic landscape of brain cells from patients with psychiatric disorders will contribute to understanding the… read more here.
Keywords: schizophrenia; dmrs; analysis; gene ... See more keywords
CDKN1C hyperexpression in two patients with severe growth failure and microdeletions affecting the paternally inherited KCNQ1OT1:TSS-DMR
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Genetics"
DOI: 10.1136/jmg-2022-108700
Abstract: Background Two imprinting control centres, H19/IGF2:IG-differentialy methylated region (DMR) and KCNQ1OT1:TSS-DMR, reside on chromosome 11p15.5. Paternal deletions involving the KCNQ1OT1:TSS-DMR result in variable phenotypes, namely, normal phenotype, Silver-Russel syndrome (SRS) and fetal demise. However, expression… read more here.
Keywords: growth failure; tss dmr; dmr; kcnq1ot1 tss ... See more keywords
Clinical Outcome of Degenerative Mitral Regurgitation: Critical Importance of Echocardiographic Quantitative Assessment in Routine Practice
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DOI: 10.1161/circulationaha.117.033173
Abstract: Background: Echocardiographic quantitation of degenerative mitral regurgitation (DMR) is recommended whenever possible in clinical guidelines but is criticized and its scalability to routine clinical practice doubted. We hypothesized that echocardiographic DMR quantitation, performed in routine… read more here.
Keywords: mm2; mitral regurgitation; mortality; practice ... See more keywords
Duodenal Mucosal Resurfacing Elicits Improvement in Glycemic and Hepatic Parameters in Type 2 Diabetes—One-Year Multicenter Study Results
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DOI: 10.2337/db18-1137-p
Abstract: Aims: Duodenal Mucosal Resurfacing (DMR) is a novel endoscopic procedure which has been shown to improve glycemic control at 6 months in type 2 diabetes (T2D). It is thought to exert insulin-sensitizing effects. DMR entails… read more here.
Keywords: duodenal mucosal; study; self; mucosal resurfacing ... See more keywords
Incidences of Deep Molecular Responses and Treatment-Free Remission in de Novo CP-CML Patients
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DOI: 10.3390/cancers12092521
Abstract: Simple Summary Tyrosine kinase inhibitors (TKI) can be safely discontinued in chronic myeloid leukemia patients. Achieving a sustained deep molecular response (DMR) before stop is recommended. Currently, the proportion of patients who achieve a sustained… read more here.
Keywords: cml patients; sustained dmr; deep molecular; dmr ... See more keywords