Intramolecular oxidative rearrangement: I2/TBHP/DMSO-mediated metal free facile access to quinoxalinone derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.153268
Abstract: Abstract Iodine/TBHP/DMSO mediated oxidative rearrangement of 3-styrylquinoxalin-2(1H)-one led to the formation of 3-aroylquinoxalin-2(1H)-ones in good to high yields via Kornblum oxidation. This methodology proceeds under mild conditions via oxidative aryl migration, followed by C C… read more here.
Keywords: tbhp dmso; dmso mediated; oxidative rearrangement;
I2-DMSO-Mediated N-H/α-C(sp3)-H Difunctionalization of Tetrahydroisoquinoline: Formal [2 + 2 + 1] Annulation for the Construction of Pyrrolo[2,1-a]isoquinoline Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00813
Abstract: An I2-DMSO-mediated cascade reaction using methyl ketones and 1,2,3,4-tetrahydroisoquinolines (THIQs) as commercially available substrates has been developed for the construction of pyrrolo[2,1-a]isoquinoline derivatives. This metal-free process involves N-H/α-C(sp3)-H difunctionalization of THIQ. Two C-C bonds and… read more here.
Keywords: construction pyrrolo; dmso mediated; pyrrolo isoquinoline; sp3 difunctionalization ... See more keywords
DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C–H sulfurization: a new route to 2-aminobenzothiazoles
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DOI: 10.1039/c8ra09784d
Abstract: DMSO-initiated coupling of two isothiocyanates; Pd-catalyzed C–H sulfurization. read more here.
Keywords: mediated palladium; catalyzed cyclization; dmso mediated; palladium catalyzed ... See more keywords
Iodine-DMSO mediated conversion of N-arylcyanothioformamides to N-arylcyanoformamides and the unexpected formation of 2-cyanobenzothiazoles
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DOI: 10.1039/d2ra00049k
Abstract: Cyanoformamides are ubiquitous as useful components for assembling key intermediates and bioactive molecules. The development of an efficient and simple approach to this motif is a challenge. Herein, we demonstrate the effectiveness of the I2-DMSO… read more here.
Keywords: mediated conversion; dmso mediated; iodine dmso; arylcyanothioformamides arylcyanoformamides ... See more keywords