I2-DMSO Promoted Deaminative Coupling Reactions of Glycine Esters: Access to 5-(Methylthio)pyridazin-3(2H)-ones.
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DOI: 10.1021/acs.orglett.3c00306
Abstract: An unprecedented, one-step strategy for the synthesis of 5-(methylthio)pyridazin-3(2H)-one derivatives has been developed through iodine triggered deaminative coupling of glycine esters with methyl ketones and hydrazine hydrate in DMSO. These transformations in the absence of… read more here.
Keywords: dmso promoted; methylthio pyridazin; glycine esters; promoted deaminative ... See more keywords
The catalytic role of elemental sulfur in the DMSO-promoted oxidative coupling of methylhetarenes with amines: synthesis of thioamides and bis-aza-heterocycles
Sign Up to like & getrecommendations! Published in 2021 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo01654c
Abstract: Thioamides could be conveniently synthesized in good to excellent yields via DMSO-promoted oxidative coupling of methylhetarenes with amines in the presence of a near stoichiometric amount of sulfur (1.25 equiv.). Both aliphatic and aromatic amines… read more here.
Keywords: promoted oxidative; oxidative coupling; coupling methylhetarenes; methylhetarenes amines ... See more keywords