LAUSR

Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma

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0 Published in 2017 at "JAMA Ophthalmology"

DOI: 10.1001/jamaophthalmol.2017.4097

Abstract: Importance Retinoblastoma (Rb) is one of the first tumors to have a known genetic etiology. However, because biopsy of this tumor is contraindicated, it has not been possible to define the effects of secondary genetic… read more here.

Keywords: copy number; dna; aqueous humor; tumor derived ... See more keywords

Environmental DNA

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2 Published in 2022 at "Current Biology"

DOI: 10.1002/(issn)2637-4943

Abstract: Emilie Didaskalou and colleagues introduce the analysis of DNA form environmental samples. read more here.

Keywords: environmental dna; dna; biology;

Identification of a new Z‐DNA inducer using SYBR green 1 as a DNA conformation sensor

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1 Published in 2019 at "FEBS Letters"

DOI: 10.1002/1873-3468.13513

Abstract: Z‐DNA, which is left‐handed double‐stranded DNA, is involved in various cellular processes. However, its biological roles have not been fully evaluated due to the lack of tools available that can control the precise conformational change… read more here.

Keywords: identification new; dna; new dna; dna inducer ... See more keywords

Mycobacterium tuberculosis TetR family transcriptional regulator Rv1019 is a negative regulator of the mfd‐mazG operon encoding DNA repair proteins

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0 Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13861

Abstract: Rv1019, a member of an uncharacterized tetracycline resistance regulator family of transcriptional regulators of Mycobacterium tuberculosis H37Rv, was found to be differentially expressed during dormancy and reactivation in vitro. In this study, we show that… read more here.

Keywords: rv1019; family transcriptional; dna; mazg ... See more keywords

Irc3 is a monomeric DNA branch point‐binding helicase in mitochondria of the yeast Saccharomyces cerevisiae

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2 Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13893

Abstract: Irc3 is a superfamily II DNA helicase required for the maintenance of mitochondrial DNA stability in Saccharomyces cerevisiae. Here, we show that recombinant Irc3 is a monomeric protein and that it can form a binary… read more here.

Keywords: saccharomyces cerevisiae; dna; point; irc3 monomeric ... See more keywords

LIM protein Ajuba promotes liver cell proliferation through its involvement in DNA replication and DNA damage control

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2 Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14371

Abstract: The LIM‐domain protein Ajuba is associated with cell proliferation, a fundamental process of tissue regeneration and cancer. We report that in the liver, Ajuba expression is increased during regeneration and in tumour cells and tissues.… read more here.

Keywords: dna; cell proliferation; damage; ajuba ... See more keywords

The BRCA2 and CDKN1A‐interacting protein (BCCIP) stabilizes stalled replication forks and prevents degradation of nascent DNA

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2 Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14406

Abstract: DNA replication stress is characterized by impaired replication fork progression, causing some of the replication forks to collapse and form DNA breaks. It is a primary cause of genomic instability leading to oncogenic transformation. The… read more here.

Keywords: bccip; dna; nascent dna; replication ... See more keywords

RNA polymerase efficiently transcribes through DNA‐scaffolded, cooperative bacteriophage repressor complexes

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1 Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14447

Abstract: DNA can act as a scaffold for the cooperative binding of protein oligomers. For example, the phage 186 CI repressor forms a wheel of seven dimers wrapped in DNA with specific binding sites, while phage… read more here.

Keywords: dna; repressor; transcription; rna polymerase ... See more keywords

Coupling of binding and differential subdomain folding of the intrinsically disordered transcription factor CREB

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1 Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14554

Abstract: The cyclic AMP response element binding protein (CREB) contains a basic leucine zipper motif (bZIP) that forms a coiled coil structure upon dimerization and specific DNA binding. Although this state is well characterized, key features… read more here.

Keywords: dna; coupling binding; dna binding; binding differential ... See more keywords

Loss of tRNA methyltransferase 9 and DNA damage response genes in yeast confers sensitivity to aminoglycosides

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2 Published in 2023 at "FEBS Letters"

DOI: 10.1002/1873-3468.14591

Abstract: tRNA methyltransferase 9 (Trm9)‐catalysed tRNA modifications have been shown to translationally enhance the DNA damage response (DDR). Here, we show that Saccharomyces cerevisiae trm9Δ, distinct DNA repair and spindle assembly checkpoint (SAC) mutants are differentially… read more here.

Keywords: dna damage; dna; trna methyltransferase; damage response ... See more keywords

High‐throughput isolation of circulating tumor DNA: a comparison of automated platforms

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0 Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12415

Abstract: The emerging interest in circulating tumor DNA (ctDNA) analyses for clinical trials has necessitated the development of a high‐throughput method for fast, reproducible, and efficient isolation of ctDNA. Currently, the majority of ctDNA studies use… read more here.

Keywords: dna; circulating tumor; isolation; tumor dna ... See more keywords