PHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1320
Abstract: Abstract The Tudor domain of human PHF1 recognizes trimethylated lysine 36 on histone H3 (H3K36me3). PHF1 relies on this interaction to regulate PRC2 methyltransferase activity, localize to DNA double strand breaks and mediate nucleosome accessibility.… read more here.
Keywords: unwrapped nucleosomes; dna; accessibility; dna accessibility ... See more keywords
Nuclear S-Nitrosylation Defines an Optimal Zone for Inducing Pluripotency.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.119.042371
Abstract: BACKGROUND We found that cell-autonomous innate immune signaling causes global changes in the expression of epigenetic modifiers to facilitate nuclear reprogramming to pluripotency. A role of S-nitrosylation by inducible NO synthase (iNOS), an important effector… read more here.
Keywords: dna accessibility; generation; innate; optimal zone ... See more keywords