The adaptive potential of circular DNA accumulation in ageing cells
Sign Up to like & getrecommendations! Published in 2020 at "Current Genetics"
DOI: 10.1007/s00294-020-01069-9
Abstract: Carefully maintained and precisely inherited chromosomal DNA provides long-term genetic stability, but eukaryotic cells facing environmental challenges can benefit from the accumulation of less stable DNA species. Circular DNA molecules lacking centromeres segregate randomly or… read more here.
Keywords: potential circular; dna accumulation; circular dna; dna ... See more keywords
PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS/STING activation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70130
Abstract: Pancreatic β‐cell damage mediated by apoptosis is believed to be a main trigger of type 1 diabetes mellitus (T1DM), which is proposed as an organ‐specific autoimmune disease mediated by T cells. Nonetheless, the fundamental origins… read more here.
Keywords: accumulation triggers; dna accumulation; cytoplasmic dna; sting activation ... See more keywords