Novel approach to integrated DNA adductomics for the assessment of in vitro and in vivo environmental exposures
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2252-6
Abstract: Adductomics is expected to be useful in the characterization of the exposome, which is a new paradigm for studying the sum of environmental causes of diseases. DNA adductomics is emerging as a powerful method for… read more here.
Keywords: vitro vivo; dna; environmental exposures; approach ... See more keywords
Triple quadrupole mass spectrometry comparative DNA adductomics of Hep G2 cells following exposure to safrole.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.10.023
Abstract: A DNA adduct screening pipeline was constructed to apply triple quadrupole mass spectrometry comparative DNA adductomics to investigate the effects of the naturally-occurring plant constituent, safrole (4-allyl-1,2-methylenedioxybenzene), on human hepatoma cells, Hep G2. DNA from… read more here.
Keywords: mass spectrometry; dna; comparative dna; hep cells ... See more keywords
In Vivo Identification of Adducts from the New Hypoxia-Activated Prodrug CP-506 Using DNA Adductomics.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00329
Abstract: Many chemotherapeutic drugs exert their cytotoxicity through the formation of DNA modifications (adducts), which interfere with DNA replication, an overactive process in rapidly dividing cancer cells. Side effects from the therapy are common, however, because… read more here.
Keywords: dna; hypoxia activated; vivo identification; dna adducts ... See more keywords
A Comprehensive Database for DNA Adductomics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.908572
Abstract: The exposure of human DNA to genotoxic compounds induces the formation of covalent DNA adducts, which may contribute to the initiation of carcinogenesis. Liquid chromatography (LC) coupled with high-resolution mass spectrometry (HRMS) is a powerful… read more here.
Keywords: dna; step; dna adducts; comprehensive database ... See more keywords