Profiling the Nucleobase and Structure Selectivity of Anticancer Drugs and other DNA Alkylating Agents by RNA Sequencing
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DOI: 10.1002/cbic.201800235
Abstract: Drugs that covalently modify DNA are components of most chemotherapy regimens, often serving as first‐line treatments. Classically, the reactivity and selectivity of DNA alkylating agents has been determined in vitro with short oligonucleotides. A statistically… read more here.
Keywords: agents rna; profiling nucleobase; alkylating agents; structure ... See more keywords
Abstract 747: A new class of DNA alkylating indolino-benzodiazepine agents (BIAs) linked with a DNA binding moiety for use with antibody-drug conjugates (ADCs)
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-747
Abstract: We have previously disclosed antibody-drug conjugates (ADCs) that incorporate our highly potent novel DNA alkylating indolino-benzodiazepine (termed IGN) pseudo dimer. ADCs of these DNA alkylating IGNs were found preclinically to demonstrate better tolerability and an… read more here.
Keywords: new class; dna; moiety; antibody drug ... See more keywords
Biosynthesis of DNA-Alkylating Antitumor Natural Products
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DOI: 10.3390/molecules27196387
Abstract: DNA-alkylating natural products play an important role in drug development due to their significant antitumor activities. They usually show high affinity with DNA through different mechanisms with the aid of their unique scaffold and highly… read more here.
Keywords: dna; biosynthesis; natural products; dna alkylating ... See more keywords