O4‐Alkylated‐2‐Deoxyuridine Repair by O6‐Alkylguanine DNA Alkyltransferase is Augmented by a C5‐Fluorine Modification
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DOI: 10.1002/cbic.201700660
Abstract: Oligonucleotides containing various adducts, including ethyl, benzyl, 4‐hydroxybutyl and 7‐hydroxyheptyl groups, at the O4 atom of 5‐fluoro‐O4‐alkyl‐2′‐deoxyuridine were prepared by solid‐phase synthesis. UV thermal denaturation studies demonstrated that these modifications destabilised the duplex by approximately… read more here.
Keywords: dna alkyltransferase; fluorine modification; dna; alkylguanine dna ... See more keywords
Resolving the subtle details of human DNA alkyltransferase lesion search and repair mechanism by single-molecule studies
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DOI: 10.1073/pnas.2116218119
Abstract: Significance We directly visualize DNA translocation and lesion recognition by the O6-alkylguanine DNA alkyltransferase (AGT). Our data show bidirectional movement of AGT monomers and clusters on undamaged DNA that depended on Zn2+ occupancy of AGT.… read more here.
Keywords: dna; lesion search; dna alkyltransferase; lesion ... See more keywords