Filaggrin variations are associated with PAH metabolites in urine and DNA alterations in blood.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental research"
DOI: 10.1016/j.envres.2019.108600
Abstract: Dermal chemical exposure is common in many professions. The filaggrin protein is important for the skin barrier and variations in the filaggrin gene (FLG) may influence the uptake of chemicals via the skin, and consequently,… read more here.
Keywords: pah metabolites; metabolites urine; flg null; chimney sweeps ... See more keywords
DNA alterations in Cd133+ and Cd133- tumour cells enriched from intra-operative human colon tumour biopsies
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3206-8
Abstract: BackgroundTumour stem cells are considered important to promote disease progression, recurrence and treatment resistance following chemotherapy in colon cancer. However, genomic analyses of colorectal cancer have mainly been performed on integrated tumour tissue consisting of… read more here.
Keywords: tumour tissue; cd133 cd133; dna alterations; cell ... See more keywords
Genome-Wide DNA Alterations in X-Irradiated Human Gingiva Fibroblasts
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21165778
Abstract: While ionizing radiation (IR) is a powerful tool in medical diagnostics, nuclear medicine, and radiology, it also is a serious threat to the integrity of genetic material. Mutagenic effects of IR to the human genome… read more here.
Keywords: gingiva fibroblasts; genome wide; human gingiva; induced dna ... See more keywords
Mitochondrial DNA Alterations in Glioblastoma (GBM)
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22115855
Abstract: Glioblastoma (GBM) is an extremely aggressive tumor originating from neural stem cells of the central nervous system, which has high histopathological and genomic diversity. Mitochondria are cellular organelles associated with the regulation of cellular metabolism,… read more here.
Keywords: glioblastoma gbm; dna; alterations glioblastoma; mitochondrial dna ... See more keywords