How Does a Helicase Unwind DNA? Insights from RecBCD Helicase
Sign Up to like & getrecommendations! Published in 2018 at "BioEssays"
DOI: 10.1002/bies.201800009
Abstract: DNA helicases are a class of molecular motors that catalyze processive unwinding of double stranded DNA. In spite of much study, we know relatively little about the mechanisms by which these enzymes carry out the… read more here.
Keywords: unwind dna; recbcd helicase; dna; helicase unwind ... See more keywords
Heavy ion space radiation triggers ongoing DNA base damage by downregulating DNA repair pathways
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences in space research"
DOI: 10.1016/j.lssr.2020.07.001
Abstract: Abstract Long-duration space missions outside low earth orbit will expose astronauts to a cumulative dose of high-energy particle radiation especially to highly damaging heavy ion radiation, which poses considerable risk to astronauts’ health. The purpose… read more here.
Keywords: space; dna; radiation; dna base ... See more keywords
Mitochondrial DNA Base Editing: Good Editing Things Still Come in Small Packages.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.08.009
Abstract: The collaborative work of two HHMI groups, one at the University of Washington and the other at the Broad Institute of MIT and Harvard, led to the development of a novel molecular tool to edit… read more here.
Keywords: base editing; editing things; good editing; editing good ... See more keywords
Solvent compatible polymer functionalization with adenine, a DNA base, for API degenotoxification: Preparation and characterization
Sign Up to like & getrecommendations! Published in 2017 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2017.02.011
Abstract: Abstract This work describes for the first time a novel functionalization of poly[2,2′-( m -phenylen)-5,5′-bisbenzimidazole] (PBI), a polymer stable in a wide range of solvents, with a DNA base, adenine (PBI-A x% ). Functionalization was… read more here.
Keywords: adenine; pbi; polymer; dna base ... See more keywords
Off-target Editing by CRISPR-guided DNA base editors.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00573
Abstract: Base editing is a genome editing strategy that induces specific single nucleotide changes within genomic DNA. Two major DNA base editors, Cytosine base editors (CBEs) and Adenine base editors (ABEs), have been developed that consist… read more here.
Keywords: crispr; base editors; target editing; dna base ... See more keywords
Water Dimer-Driven DNA Base Superstructure with Mismatched Hydrogen Bonding
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c09575
Abstract: The existence of water dimers in equilibrium water vapor at room temperature and their anomalous properties revealed by recent studies suggest the benchmark role of water dimers in both experiment and theory. However, there has… read more here.
Keywords: mismatched hydrogen; water dimers; water; dna base ... See more keywords
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.
Sign Up to like & getrecommendations! Published in 2021 at "Nature cell biology"
DOI: 10.1038/s41556-021-00792-w
Abstract: Genetic defects in the repair of DNA single-strand breaks (SSBs) can result in neurological disease triggered by toxic activity of the single-strand-break sensor protein PARP1. However, the mechanism(s) by which this toxic PARP1 activity triggers… read more here.
Keywords: parp1 activity; dna base; parp1; activity ... See more keywords
CRISPR DNA base editors with reduced RNA off-target and self-editing activities
Sign Up to like & getrecommendations! Published in 2019 at "Nature biotechnology"
DOI: 10.1038/s41587-019-0236-6
Abstract: Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T or A-to-G alterations1–4. However, we recently demonstrated that they can also induce transcriptome-wide guide-RNA-independent editing of RNA bases5, and created selective curbing… read more here.
Keywords: base editors; rna; target; dna base ... See more keywords
Cooperative vibrational properties of hydrogen bonds in Watson–Crick DNA base pairs
Sign Up to like & getrecommendations! Published in 2017 at "New Journal of Chemistry"
DOI: 10.1039/c7nj03088f
Abstract: A detailed analysis of hydrogen bonding (H-bonding) nuclear motions is presented for adenine–thymine (AT) and guanine–cytosine (GC) Watson–Crick DNA base pairs. Using first-principles calculations, we investigated the infrared (IR) spectroscopy and nuclear vibrating patterns of… read more here.
Keywords: watson crick; crick dna; base pairs; dna base ... See more keywords
CuII-mediated DNA base pairing of a triazole-4-carboxylate nucleoside prepared by click chemistry.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06205d
Abstract: Artificial metal-mediated DNA base pairing is a promising strategy for creating highly functionalized DNA supramolecules. Here we report a novel ligand-type triazole-4-carboxylate (TazC) nucleoside that is readily prepared by the click reaction. TazC nucleosides were… read more here.
Keywords: mediated dna; base pairing; chemistry; triazole carboxylate ... See more keywords
Lamin A/C promotes DNA base excision repair.
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic acids research"
DOI: 10.1093/nar/gkz912
Abstract: The A-type lamins (lamin A/C), encoded by the LMNA gene, are important structural components of the nuclear lamina. LMNA mutations lead to degenerative disorders known as laminopathies, including the premature aging disease Hutchinson-Gilford progeria syndrome.… read more here.
Keywords: dna base; excision repair; base excision; repair ... See more keywords