Free Energy Coupling between DNA Bending and Base Flipping.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00215
Abstract: Free energy simulations are presented to probe the energetic coupling between DNA bending and the flipping of a central thymine in double stranded DNA 13mers. The energetics are shown to depend on the neighboring base… read more here.
Keywords: dna bending; dna; base; free energy ... See more keywords
A DNA origami-based device for investigating DNA bending proteins by transmission electron microscopy.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d2nr05366g
Abstract: The DNA origami technique offers precise positioning of nanoscale objects with high accuracy. This has facilitated the development of DNA origami-based functional nanomechanical devices that enable the investigation of DNA-protein interactions at the single particle… read more here.
Keywords: origami based; dna; microscopy; dna bending ... See more keywords
Fluidification of Entanglements by a DNA Bending Protein.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review letters"
DOI: 10.1103/physrevlett.130.058203
Abstract: In spite of the nanoscale and single-molecule insights into nucleoid associated proteins (NAPs), their role in modulating the mesoscale viscoelasticity of entangled DNA has been overlooked so far. By combining microrheology and molecular dynamics simulation,… read more here.
Keywords: dna bending; bending protein; entanglements dna; fluidification entanglements ... See more keywords
Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.21777
Abstract: The transposition of bacteriophage Mu serves as a model system for understanding DDE transposases and integrases. All available structures of these enzymes at the end of the transposition reaction, including Mu, exhibit significant bends in… read more here.
Keywords: dna bending; target dna; target; transposition ... See more keywords