Coupling of binding and differential subdomain folding of the intrinsically disordered transcription factor CREB
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14554
Abstract: The cyclic AMP response element binding protein (CREB) contains a basic leucine zipper motif (bZIP) that forms a coiled coil structure upon dimerization and specific DNA binding. Although this state is well characterized, key features… read more here.
Keywords: dna; coupling binding; dna binding; binding differential ... See more keywords
The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14675
Abstract: The architectural chromatin factor high-mobility group AT-hook 2 (HMGA2) is causally involved in several human malignancies and pathologies. HMGA2 is not expressed in most normal adult somatic cells, which renders the protein an attractive drug… read more here.
Keywords: fgfr inhibitor; dna binding; hmga2; inhibitor pd173074 ... See more keywords
Mitotic phosphorylation of CCCTC‐binding factor (CTCF) reduces its DNA binding activity
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12189
Abstract: During mitosis, higher order chromatin structures are disrupted and chromosomes are condensed to achieve accurate chromosome segregation. CCCTC‐binding factor (CTCF) is a highly conserved and ubiquitously expressed C2H2‐type zinc finger protein which is considered to… read more here.
Keywords: mitosis; ctcf; dna binding; binding activity ... See more keywords
DNA‐Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800273
Abstract: DNA minor groove binding polyamides have been extensively developed to control abnormal gene expression. The establishment of novel, inherently fluorescent 2‐(p‐anisyl)benzimidazole (Hx) amides has provided an alternative path for studying DNA binding in cells by… read more here.
Keywords: azahx; pyr azahx; dna; azahx amides ... See more keywords
DNA Morphology: Global Alteration of DNA Topological States Induced by Chemotherapeutic Agents and Its Implication in Cancer
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200715
Abstract: The dynamic topological states of chromosomal DNA regulate many cellular fundamental processes universally in all three domains of life, that is, bacteria, archaea, and eukaryotes. DNA‐binding proteins maintain the regional and global supercoiling of the… read more here.
Keywords: dna morphology; dna; dna binding; chemotherapeutic agents ... See more keywords
Acridine/Acridone–Carborane Conjugates as Strong DNA‐Binding Agents with Anticancer Potential
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200666
Abstract: Synthesis of acridine derivatives that act as DNA‐targeting anticancer agents is an evolving field and has resulted in the introduction of several drugs into clinical trials. Carboranes can be of importance in designing biologically active… read more here.
Keywords: dna; acridine; acridone carborane; dna binding ... See more keywords
TAR DNA‐binding protein 43 oligomers in physiology and pathology
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2603
Abstract: TAR DNA‐binding protein 43 (TDP‐43) is an RNA/DNA‐binding protein involved in RNA regulation and diseases. In 2006, TDP‐43 inclusions were found in the disease lesions of several neurodegenerative diseases. It is the pathological hallmark in… read more here.
Keywords: binding protein; dna binding; pathology; physiology ... See more keywords
Distribution and characteristics of transactive response DNA binding protein 43 kDa pathology in progressive supranuclear palsy
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26809
Abstract: This study aimed to determine the frequency of transactive response DNA binding protein 43 kDa pathology in PSP, the clinical features of patients with this pathology, and genetic risk factors for it. read more here.
Keywords: pathology; transactive response; binding protein; dna binding ... See more keywords
Structural insights into DNA binding domain of vancomycin‐resistance‐associated response regulator in complex with its promoter DNA from Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4286
Abstract: In Staphylococcus aureus, vancomycin‐resistance‐associated response regulator (VraR) is a part of the VraSR two‐component system, which is responsible for activating a cell wall‐stress stimulon in response to an antibiotic that inhibits cell wall formation. Two… read more here.
Keywords: dna; vancomycin resistance; dna binding; staphylococcus aureus ... See more keywords
Structure and DNA binding analysis of AT‐rich interaction domain present in human BAF‐B specific subunit BAF250b
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4294
Abstract: BAF250b and its paralog BAF250a are the DNA‐binding central hub proteins present in BAF‐B and BAF‐A classes of SWI/SNF chromatin‐remodeling complexes. BAF250b contains an AT‐rich interaction domain (ARID) and C‐terminal BAF250_C domain, and it is… read more here.
Keywords: baf250b arid; dna; structure; dna binding ... See more keywords
Multifunctional Heterogeneous Carbon Nanotube Nanocomposites Assembled by DNA-Binding Peptide Anchors.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.201905821
Abstract: Although carbon nanotubes (CNTs) are remarkable materials with many exceptional characteristics, their poor chemical functionality limits their potential applications. Herein, a strategy is proposed for functionalizing CNTs, which can be achieved with any functional group… read more here.
Keywords: multifunctional heterogeneous; binding peptide; heterogeneous carbon; dna ... See more keywords