Coupling of binding and differential subdomain folding of the intrinsically disordered transcription factor CREB
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14554
Abstract: The cyclic AMP response element binding protein (CREB) contains a basic leucine zipper motif (bZIP) that forms a coiled coil structure upon dimerization and specific DNA binding. Although this state is well characterized, key features… read more here.
Keywords: dna; coupling binding; dna binding; binding differential ... See more keywords
The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14675
Abstract: The architectural chromatin factor high-mobility group AT-hook 2 (HMGA2) is causally involved in several human malignancies and pathologies. HMGA2 is not expressed in most normal adult somatic cells, which renders the protein an attractive drug… read more here.
Keywords: fgfr inhibitor; dna binding; hmga2; inhibitor pd173074 ... See more keywords
Mitotic phosphorylation of CCCTC‐binding factor (CTCF) reduces its DNA binding activity
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12189
Abstract: During mitosis, higher order chromatin structures are disrupted and chromosomes are condensed to achieve accurate chromosome segregation. CCCTC‐binding factor (CTCF) is a highly conserved and ubiquitously expressed C2H2‐type zinc finger protein which is considered to… read more here.
Keywords: mitosis; ctcf; dna binding; binding activity ... See more keywords
The effect of Cu(II) ion on antioxidant and DNA‐binding mechanism of baicalein and scutellarein: Spectroscopic, theoretical, and molecular docking study
Sign Up to like & getrecommendations! Published in 2024 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.7390
Abstract: Flavonoids are a group of polyphenolic compounds known to possess good radical scavenging activity. It was also shown that their anti/prooxidant properties are strongly structure‐dependent and can be modified by metal ion binding. The structural… read more here.
Keywords: molecular docking; spectroscopic theoretical; effect; ion ... See more keywords
Elucidation of mode of anticancerous activity of metal guanidinobenzimidazoles: A computational and experimental screening
Sign Up to like & getrecommendations! Published in 2024 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.7654
Abstract: DNA‐binding agents often exhibits dual behavior of simultaneous binding with protein associated with cancerous cell development pathways. This simultaneous protein binding if contributed to malfunctioning of pro‐apoptotic proteins will reduce anticancerous potential of drugs. The… read more here.
Keywords: elucidation; cell; dna binding; dna ... See more keywords
DNA‐Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800273
Abstract: DNA minor groove binding polyamides have been extensively developed to control abnormal gene expression. The establishment of novel, inherently fluorescent 2‐(p‐anisyl)benzimidazole (Hx) amides has provided an alternative path for studying DNA binding in cells by… read more here.
Keywords: azahx; pyr azahx; dna; azahx amides ... See more keywords
DNA Morphology: Global Alteration of DNA Topological States Induced by Chemotherapeutic Agents and Its Implication in Cancer
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200715
Abstract: The dynamic topological states of chromosomal DNA regulate many cellular fundamental processes universally in all three domains of life, that is, bacteria, archaea, and eukaryotes. DNA‐binding proteins maintain the regional and global supercoiling of the… read more here.
Keywords: dna morphology; dna; dna binding; chemotherapeutic agents ... See more keywords
Acridine/Acridone–Carborane Conjugates as Strong DNA‐Binding Agents with Anticancer Potential
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200666
Abstract: Synthesis of acridine derivatives that act as DNA‐targeting anticancer agents is an evolving field and has resulted in the introduction of several drugs into clinical trials. Carboranes can be of importance in designing biologically active… read more here.
Keywords: dna; acridine; acridone carborane; dna binding ... See more keywords
DNA Binding Activity of Functionalized Schiff Base Metal Complexes
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.202400705
Abstract: Based on our recent research experience, this review highlights the DNA binding of salen, salphen and salnaphen metal complexes, with a focus on G‐quadruplex (G4) DNA, which is crucial in peculiar genomic regions and in… read more here.
Keywords: binding activity; functionalized schiff; metal; activity functionalized ... See more keywords
TAR DNA‐binding protein 43 oligomers in physiology and pathology
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2603
Abstract: TAR DNA‐binding protein 43 (TDP‐43) is an RNA/DNA‐binding protein involved in RNA regulation and diseases. In 2006, TDP‐43 inclusions were found in the disease lesions of several neurodegenerative diseases. It is the pathological hallmark in… read more here.
Keywords: binding protein; dna binding; pathology; physiology ... See more keywords
Aziridine‐Functionalized 1,3,5‐Triazine Derivatives as Promising Anticancer Agents: Synthesis, DFT Study, DNA Binding Investigations and In Vitro Cytotoxic Activity
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.4908
Abstract: Herein, we report a synthesis and characterization of aziridine‐functionalized 1,3,5‐triazine derivatives. Electronic structure and the most preferable geometry of substances were calculated by DFT method. DNA binding investigations were conducted as part of the biomedicinal… read more here.
Keywords: aziridine functionalized; triazine derivatives; functionalized triazine; cytotoxic activity ... See more keywords