A New DNA Break Repair Pathway Involving PARP3 and Base Excision Repair Proteins
Sign Up to like & getrecommendations! Published in 2018 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672918050010
Abstract: Poly(ADP-ribosyl)ation, which is catalyzed by PARP family proteins, is one of the main reactions in the cell response to genomic DNA damage. Massive impact of DNA-damaging agents (such as oxidative stress and ionizing radiation) causes… read more here.
Keywords: break repair; base excision; dna; excision repair ... See more keywords
Profiling DNA break sites and transcriptional changes in response to contextual fear learning
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DOI: 10.1371/journal.pone.0249691
Abstract: Neuronal activity generates DNA double-strand breaks (DSBs) at specific loci in vitro and this facilitates the rapid transcriptional induction of early response genes (ERGs). Physiological neuronal activity, including exposure of mice to learning behaviors, also… read more here.
Keywords: transcriptional changes; profiling dna; response; dna break ... See more keywords
Does single strand DNA break repair capacity influence oocyte maintenance and quality?
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DOI: 10.1530/rep-22-0325
Abstract: Human genome-wide association studies and evidence from animal models link ovarian ageing to double-stranded (ds) DNA break repair capacity. Is there a connection between single-stranded (ss)DNA repair mechanisms and ovarian function? We hypothesize that endogenous… read more here.
Keywords: dna break; repair capacity; break repair; repair ... See more keywords
Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein-level changes
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DOI: 10.26508/lsa.202201454
Abstract: The meiotic DNA break response is shown to involve a large number of phosphorylation changes and a clearly detectable transcriptional response. By contrast, the meiotic proteome remains remarkably unchanged in response to breaks. Meiotic cells… read more here.
Keywords: dna; meiotic dna; dna breaks; dna break ... See more keywords