Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies
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DOI: 10.1158/1078-0432.ccr-18-2207
Abstract: Purpose: DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types and is strongly associated with poor outcome. The underlying mechanisms… read more here.
Keywords: dna; targeting dna; cancer; pleiotropic impact ... See more keywords
Targeting G-Quadruplex Dna For Cancer Chemotherapy.
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DOI: 10.2174/1570163819666220214115408
Abstract: The self-association of DNA formed by Hoogsteen hydrogen bonding comprises several layers of four guanine or G-tetrads or G4s. The distinct feature of G4s, such as the G-tetrads and loops, qualify structure-selective recognition by small… read more here.
Keywords: dna; quadruplex dna; dna cancer; targeting quadruplex ... See more keywords