Biodistribution of Graphene Oxide Determined through Postadministration Labeling with DNA-Conjugated Gold Nanoparticles and ICPMS.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c02909
Abstract: Recent research has revealed the use of graphene oxide (GO) and its derivatives as a potential biomaterial because of their attractive physicochemical characteristics and functional properties. However, if GO and related derivatives are to become… read more here.
Keywords: graphene oxide; biodistribution; dna; dna conjugated ... See more keywords
DNA Compatible Intermolecular Wittig Olefination for the Construction of α, β-Unsaturated Carbonyl Compounds.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01215
Abstract: A robust DNA-compatible Wittig reaction mediated by PPh2CH3 has been validated for DNA-conjugated α-chloroacetamides with aldehydes and, alternatively, DNA-conjugated aldehydes with α-halo acetamides or ketones. Further, 2-aminopyridines were acylated with α-chloroacetyl chloride and then reacted… read more here.
Keywords: dna compatible; carbonyl compounds; compatible intermolecular; unsaturated carbonyl ... See more keywords
Mild and Efficient Palladium-Mediated C-N Cross-Coupling Reaction between DNA-Conjugated Aryl Bromides and Aromatic Amines.
Sign Up to like & getrecommendations! Published in 2019 at "ACS combinatorial science"
DOI: 10.1021/acscombsci.8b00142
Abstract: DNA-encoded library technology (ELT) has emerged in the pharmaceutical industry as a powerful tool for hit and lead generation. Over the last 10 years, a number of DNA-compatible chemical reactions have been published and used… read more here.
Keywords: dna conjugated; dna; coupling reaction; reaction ... See more keywords
CODEX multiplexed tissue imaging with DNA-conjugated antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "Nature protocols"
DOI: 10.1038/s41596-021-00556-8
Abstract: Advances in multiplexed imaging technologies have drastically improved our ability to characterize healthy and diseased tissues at the single-cell level. Co-detection by indexing (CODEX) relies on DNA-conjugated antibodies and the cyclic addition and removal of… read more here.
Keywords: conjugated antibodies; antibodies codex; codex; dna conjugated ... See more keywords
Nuclear formation induced by DNA-conjugated beads in living fertilised mouse egg
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44941-6
Abstract: Reformation of a functional nucleus at the end of mitosis is crucial for normal cellular activity. Reconstitution approaches using artificial beads in frog egg extracts have clarified the molecules required for nuclear formation in vitro.… read more here.
Keywords: conjugated beads; dna; egg; dna conjugated ... See more keywords
Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.851674
Abstract: C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described… read more here.
Keywords: dna; dna conjugated; chemistry; hydroamination ... See more keywords