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Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/nn.4626
Abstract: Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA–RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism…
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Keywords:
dna contract;
kill neurons;
loopholes dna;
contract kill ... See more keywords