Radiomic Analysis of Contrast-Enhanced MRI Predicts DNA Copy-Number Subtype and Outcome in Lower-Grade Gliomas.
Sign Up to like & getrecommendations! Published in 2021 at "Academic radiology"
DOI: 10.1016/j.acra.2021.10.014
Abstract: RATIONALE AND OBJECTIVES DNA copy-number (CN)2-subtype impairs outcomes in patients with lower-grade gliomas (LGG). We aimed to determine the value of preoperative nomograms integrating radiomic and radiographic (RR) features in predicting DNA copy-number subtype. METHODS… read more here.
Keywords: number subtype; dna copy; subtype; copy number ... See more keywords
Air pollution and placental mitochondrial DNA copy number: Mechanistic insights and epidemiological challenges.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental pollution"
DOI: 10.1016/j.envpol.2019.113266
Abstract: During embryogenesis and embryo implantation, the copy number of mtDNA is elaborately regulated to meet the cellular demand for division, growth and differentiation. With large numbers of mitochondria for energy production, placental cells possess strong… read more here.
Keywords: mitochondrial dna; dna copy; copy number; copy ... See more keywords
Depressive Symptoms Predict Change in Telomere Length and Mitochondrial DNA Copy Number Across Adolescence.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Academy of Child and Adolescent Psychiatry"
DOI: 10.1016/j.jaac.2019.09.031
Abstract: OBJECTIVE Several studies have found associations between a diagnosis or symptoms of major depressive disorder and markers of cellular aging and dysfunction. These investigations, however, are predominantly cross-sectional and focus on adults. In the present… read more here.
Keywords: depressive symptoms; cellular aging; telomere length; dna copy ... See more keywords
Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84132-w
Abstract: Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with… read more here.
Keywords: mitochondrial dna; copy number; dna copy; mtdna ... See more keywords
The polymorphisms in cGAS-STING pathway are associated with mitochondrial DNA copy number in coke oven workers.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of environmental health research"
DOI: 10.1080/09603123.2022.2071418
Abstract: OBJECTIVE To evaluate the interaction effects of Polycyclic aromatic hydrocarbons (PAHs) exposure and variants in cGAS-STING genes on mitochondrial DNA copy number (mtDNAcn) in workers. METHODS The mtDNAcn was determined by real-time quantitative polymerase-chain reaction… read more here.
Keywords: dna copy; mitochondrial dna; cgas sting; copy number ... See more keywords
Maternal Lifetime Stress and Prenatal Psychological Functioning and Decreased Placental Mitochondrial DNA Copy Number in the PRISM Study
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwx183
Abstract: Psychosocial stress contributes to placental oxidative stress. Mitochondria are vulnerable to oxidative stress, which can lead to changes in mitochondrial DNA copy number (mtDNAcn). We examined associations of maternal lifetime stress, current negative life events,… read more here.
Keywords: lifetime stress; mtdnacn; copy number; dna copy ... See more keywords
Mitochondrial DNA copy number in peripheral blood leukocytes is associated with biochemical recurrence in prostate cancer patients in African Americans.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz139
Abstract: Mitochondria play multiple important cellular functions. The purpose of this study was to evaluate whether leukocyte mitochondrial DNA copy number (mtDNAcn) is associated with aggressive prostate cancer (PCa) in African American (AA) men. We measured… read more here.
Keywords: mtdnacn; copy number; prostate cancer; dna copy ... See more keywords
Influence of environmental factors and genetic variation on mitochondrial DNA copy number.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal science"
DOI: 10.1093/jas/skac059
Abstract: Mitochondrial DNA copy number (mtDNA CN) has been shown to be highly heritable and associated with traits of interest in humans. However, studies are lacking in the literature for livestock species such as beef cattle.… read more here.
Keywords: dna; dna copy; mitochondrial dna; mtdna ... See more keywords
Variations in ribosomal DNA copy numbers in a genome of Trichophyton interdigitale
Sign Up to like & getrecommendations! Published in 2020 at "Mycoses"
DOI: 10.1111/myc.13163
Abstract: Ribosomal DNA (rDNA) reportedly has multiple copies in the fungal genome. The internal transcribed spacer (ITS) region in rDNA is useful for investigating relationships between close taxonomic relatives. Thus, ITS has been widely used as… read more here.
Keywords: trichophyton interdigitale; variations ribosomal; dna copy; genome trichophyton ... See more keywords
FrenchFISH: Poisson Models for Quantifying DNA Copy Number From Fluorescence In Situ Hybridization of Tissue Sections
Sign Up to like & getrecommendations! Published in 2021 at "JCO Clinical Cancer Informatics"
DOI: 10.1200/cci.20.00075
Abstract: PURPOSE Chromosomal aberration and DNA copy number change are robust hallmarks of cancer. The gold standard for detecting copy number changes in tumor cells is fluorescence in situ hybridization (FISH) using locus-specific probes that are… read more here.
Keywords: tissue sections; dna copy; copy number; number ... See more keywords
The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0275394
Abstract: To study neoplasia in tissue culture, cell lines representing the evolution of normal cells to tumor cells are needed. To produce such cells, we developed the AGMK1-9T7 cell line, established cell banks at 10-passage intervals,… read more here.
Keywords: cell; dna copy; number; copy number ... See more keywords