Biotin-tagged cis-dichlorido-oxidovanadium(IV) complex for DNA crosslinking and photo-induced apoptotic cytotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2021.120629
Abstract: Abstract Cis-dichlorido-oxidovanadium(IV) complexes [VO(dpa/L1)Cl2] (1, 2) of dipicolylamine (dpa, 1 as control species) and 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid (biotin)-appended dpa (L1, 2 as active species) were prepared and their anticancer activity studied. Single crystal X-ray diffraction analysis… read more here.
Keywords: biotin; cis dichlorido; dna crosslinking; photo induced ... See more keywords
Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69682-9
Abstract: Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDCs with varying… read more here.
Keywords: crosslinking agent; dna crosslinking; dna; folate ... See more keywords
Arterial Administration of DNA Crosslinking Agents with Restraint of Homologous Recombination Repair by Intravenous Low-Dose Gemcitabine Is Effective for Locally Advanced Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14010220
Abstract: Simple Summary Pancreatic cancer is considered incurable, and most cases are detected in the advanced stages. Establishing a new, effective interventional treatment for advanced pancreatic cancer is a pressing issue. Pretreatment with gemcitabine had a… read more here.
Keywords: dna crosslinking; pancreatic cancer; advanced pancreatic; treatment ... See more keywords