DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19941-0
Abstract: Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of PRKDC encoding the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) are associated with… read more here.
Keywords: antiviral innate; dna deficiency; cgas mediated; dna ... See more keywords