Dendritic cell upregulation of programmed death ligand-1 via DNA demethylation inhibits experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.102362
Abstract: Dendritic cells (DCs) play key roles in regulating T cell proliferation and differentiation, and epigenetic modification involves in this process. In the periphery, programmed death ligand-1 (PD-L1) expressed on antigen-presenting cells interacts with programmed death-1… read more here.
Keywords: dna; programmed death; death ligand; dna demethylation ... See more keywords
MicroRNA-29 impairs the early phase of reprogramming process by targeting active DNA demethylation enzymes and Wnt signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cell research"
DOI: 10.1016/j.scr.2016.12.020
Abstract: Somatic cell reprogramming by transcription factors and other modifiers such as microRNAs has opened broad avenues for the study of developmental processes, cell fate determination, and interplay of molecular mechanisms in signaling pathways. However, many… read more here.
Keywords: wnt signaling; active dna; mir; microrna impairs ... See more keywords
Maintenance DNA Methyltransferase Activity in the Presence of Oxidized Forms of 5-Methylcytosine: Structural Basis for Ten Eleven Translocation-Mediated DNA Demethylation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00683
Abstract: A precise balance of DNA methylation and demethylation is required for epigenetic control of cell identity, development, and growth. DNA methylation marks are introduced by de novo DNA methyltransferases DNMT3a/b and are maintained throughout cell… read more here.
Keywords: dna; demethylation; oxidized forms; dna demethylation ... See more keywords
Combination of DNA demethylation and chemotherapy to trigger cell pyroptosis for inhalation treatment of lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Nanoscale"
DOI: 10.1039/d1nr05001j
Abstract: Pyroptosis is an inflammation-dependent and self-cascade amplifying type of programmed cell death, serving as an effective means for activating the local immune response and improving the anticancer efficacy. As the effector of pyroptosis, gasdermin-E (GSDME)… read more here.
Keywords: pyroptosis; dna demethylation; cell; lung cancer ... See more keywords
5-hydroxymethylcytosine in DNA repair: A new player or a red herring?
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1346761
Abstract: ABSTRACT Active DNA demethylation performed by ten-eleven translocation (TET) enzymes produces 5-hydroxymethylcytosines, 5-formylcytosines, and 5-carboxylcytosines. Recent observations suggest that 5-hydroxymethylcytosine is a stable epigenetic mark rather than merely an intermediate of DNA demethylation. However, the… read more here.
Keywords: hydroxymethylcytosine; dna repair; dna; player ... See more keywords
A novel protein complex that regulates active DNA demethylation in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13045
Abstract: Active DNA demethylation is critical for altering DNA methylation patterns and regulating gene expression. The 5-methylcytosine DNA glycosylase/lyase ROS1 initiates a base excision repair pathway for active DNA demethylation and is required for the prevention… read more here.
Keywords: protein; active dna; dna; genomic regions ... See more keywords
DEMETHYLATION REGULATOR 1 regulates DNA demethylation of the nuclear and mitochondrial genomes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13386
Abstract: Active DNA demethylation effectively modulates gene expression during plant development and in response to stress. However, little is known about the upstream regulatory factors that regulate DNA demethylation. We determined that the demethylation regulator 1… read more here.
Keywords: demethylation nuclear; demethylation; dna demethylation; demethylation regulator ... See more keywords
Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro‐myelinating genes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15015
Abstract: Ascorbic acid (vitamin C) is critical for Schwann cells to myelinate peripheral nerve axons during development and remyelination after injury. However, its exact mechanism remains elusive. Vitamin C is a dietary nutrient that was recently… read more here.
Keywords: myelinating genes; myelination; pro myelinating; dna demethylation ... See more keywords
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm3470
Abstract: Ten-eleven translocation (Tet) enzymes promote DNA demethylation by oxidizing 5-methylcytosine. They are expressed during development and are essential for mouse gastrulation. However, their postgastrulation functions are not well established. We find that global or endothelial-specific… read more here.
Keywords: stem progenitor; dna demethylation; hematopoietic stem; progenitor cells ... See more keywords
Active DNA demethylation promotes cell fate specification and the DNA damage response
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.add9838
Abstract: Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogenous damage remains unclear. Using two systems of postmitotic lineage specification—induced pluripotent stem cell–derived neurons… read more here.
Keywords: active dna; dna demethylation; dna; dna damage ... See more keywords
Tet-Mediated DNA Demethylation Is Required for SWI/SNF-Dependent Chromatin Remodeling and Histone-Modifying Activities That Trigger Expression of the Sp7 Osteoblast Master Gene during Mesenchymal Lineage Commitment
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00177-17
Abstract: ABSTRACT Here we assess histone modification, chromatin remodeling, and DNA methylation processes that coordinately control the expression of the bone master transcription factor Sp7 (osterix) during mesenchymal lineage commitment in mammalian cells. We find that… read more here.
Keywords: chromatin remodeling; expression; dna demethylation; gene ... See more keywords