Are Anaphase Events Really Irreversible? The Endmost Stages of Cell Division and the Paradox of the DNA Double‐Strand Break Repair
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DOI: 10.1002/bies.202000021
Abstract: It has been recently demonstrated that yeast cells are able to partially regress chromosome segregation in telophase as a response to DNA double‐strand breaks (DSBs), likely to find a donor sequence for homology‐directed repair (HDR).… read more here.
Keywords: double strand; anaphase events; dna double; repair ... See more keywords
Characterization of DNA double‐strand break repair pathways in diffuse large B cell lymphoma
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DOI: 10.1002/mc.22921
Abstract: Efficient DNA repair is indispensable for maintaining genomic integrity in humans. Cancer associated deletions and mutations are mainly due to misrepaired DNA double‐strand breaks (DSBs). Classical nonhomologous end joining (c‐NHEJ) and homologous recombination (HR) are… read more here.
Keywords: lymphoma; repair pathways; dna double; cell ... See more keywords
DNA Double-Strand Break-Induced Gene Amplification in Yeast.
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DOI: 10.1007/978-1-0716-0644-5_17
Abstract: Precise control of the gene copy number in the model yeast Saccharomyces cerevisiae may facilitate elucidation of enzyme functions or, in cell factory design, can be used to optimize production of proteins and metabolites. Currently,… read more here.
Keywords: induced gene; dna double; strand break; double strand ... See more keywords
Sequencing Spo11 Oligonucleotides for Mapping Meiotic DNA Double-Strand Breaks in Yeast.
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DOI: 10.1007/978-1-4939-6340-9_3
Abstract: Meiosis is a specialized form of cell division resulting in reproductive cells with a reduced, usually haploid, genome complement. A key step after premeiotic DNA replication is the occurrence of homologous recombination at multiple places… read more here.
Keywords: dna; sequencing spo11; dna double; strand breaks ... See more keywords
Radiation-induced DNA double-strand breaks in peripheral leukocytes and therapeutic response of heel spur patients treated by orthovoltage X-rays or a linear accelerator
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DOI: 10.1007/s00066-020-01662-4
Abstract: Purpose Biodosimetric assessment and comparison of radiation-induced deoxyribonucleic acid (DNA) double-strand breaks (DSBs) by γH2AX immunostaining in peripheral leukocytes of patients with painful heel spur after radiation therapy (RT) with orthovoltage X‑rays or a 6-MV linear… read more here.
Keywords: response; radiation induced; orthovoltage rays; dna double ... See more keywords
RAP80, ubiquitin and SUMO in the DNA damage response
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DOI: 10.1007/s00109-017-1561-1
Abstract: A decade has passed since the first reported connection between RAP80 and BRCA1 in DNA double-strand break repair. Despite the initial identification of RAP80 as a factor localizing BRCA1 to DNA double-strand breaks and potentially… read more here.
Keywords: rap80; ubiquitin sumo; dna; dna double ... See more keywords
Possible scenarios of DNA double-helix unzipping process in single-molecule manipulation experiments
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DOI: 10.1007/s00249-018-1313-3
Abstract: AbstractSingle-molecule experiments on DNA unzipping are analyzed on the basis of the mobility of nucleic bases in complementary pairs. Two possible scenarios of DNA double-helix unzipping are proposed and studied, using the atom–atom potential function… read more here.
Keywords: double helix; scenarios dna; scenario; dna double ... See more keywords
Analyses of DNA double-strand break repair pathways in tandem arrays of HXT genes of Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of microbiology"
DOI: 10.1007/s12275-020-0461-1
Abstract: Eukaryotic genomes contain numerous homologous repeat sequences including redundant genes with divergent homology that can be potential recombination targets. Recombination between divergent sequences is rare but poses a substantial threat to genome stability. The hexose… read more here.
Keywords: tandem arrays; dna double; hxt genes; double strand ... See more keywords
Magnetic studies of Co 2+ , Ni 2+ , and Zn 2+ -modified DNA double-crossover lattices
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DOI: 10.1016/j.apsusc.2017.08.069
Abstract: Abstract We fabricated divalent-metal-ion-modified DNA double-crossover (DX) lattices on a glass substrate and studied their magnetic characteristics as a function of ion concentrations [Co 2+ ], [Ni 2+ ] and [Zn 2+ ]. Up to… read more here.
Keywords: dna lattices; dna; dna double; double crossover ... See more keywords
53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function
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DOI: 10.1016/j.celrep.2019.06.035
Abstract: Summary Class switch recombination (CSR) is a DNA recombination reaction that diversifies the effector functions of antibodies. CSR occurs via the formation and non-homologous end joining (NHEJ) repair of programmed DNA double-strand breaks (DSBs) at… read more here.
Keywords: end; dna double; class switch; switch recombination ... See more keywords
The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair.
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DOI: 10.1016/j.celrep.2021.109306
Abstract: 53BP1 is recruited to chromatin in the vicinity of DNA double-strand breaks (DSBs). We identify the nuclear kinesin, KIF18B, as a 53BP1-interacting protein and define its role in 53BP1-mediated DSB repair. KIF18B is a molecular… read more here.
Keywords: nuclear kinesin; kif18b; dna double; double strand ... See more keywords