Effect of Methyl Group on Acyclic Serinol Scaffold for Tethering Dyes on the DNA Duplex Stability
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201600558
Abstract: Acyclic serinol derivatives are useful scaffolds for tethering dyes within DNA duplexes. Here we synthesised an inverse l‐threoninol (il‐threoninol) scaffold and compared its effect on DNA duplex stability to other acyclic artificial nucleic acid scaffolds… read more here.
Keywords: threoninol; dna; effect; serinol ... See more keywords
Investigating the Stability of DNA Duplex Hairpins using Optical Tweezers
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.412
Abstract: Covalent modifications and replication errors lead to DNA damage and mutation. Such errors occur frequently throughout the genome, disrupting the stability of the double helix. The 8-oxoguanine (8-oxoG) lesion, one of the most widespread forms… read more here.
Keywords: investigating stability; stability dna; duplex hairpins; stability ... See more keywords
Electronic structure, vibrational assignments and simulation studies with A/T rich DNA duplex of an aromatic bis-amidine derivative.
Sign Up to like & getrecommendations! Published in 2017 at "DNA repair"
DOI: 10.1016/j.dnarep.2017.10.005
Abstract: In this paper, computational investigations have been carried out on an aromatic bis-amidine which is considered to be crucial due to its peculiar properties including anti-Pneumocystis carinii pneumonia(PCP), anti-inflammatory and anticancer activities. The raw structure… read more here.
Keywords: bis amidine; aromatic bis; dna duplex; dna ... See more keywords
Structural modification of nonspecific thiazole orange for ligand-DNA interaction study: Understanding the ligand recognition selectivity towards G4-DNA over duplex-DNA
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Luminescence"
DOI: 10.1016/j.jlumin.2020.117488
Abstract: Abstract The study of ligand interactions with nucleic acid structures such as G-quadruplexes versus double-stranded DNA is important because these interactions are fundamental for many intracellular processes. In the investigation of ligand-DNA binding process, achieving… read more here.
Keywords: towards dna; duplex dna; dna; study ... See more keywords
Reduction-Responsive DNA Duplex Containing O6-Nitrobenzyl-Guanine
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DOI: 10.1021/acsomega.8b01177
Abstract: Stimuli-controlled structural transitions of nucleic acids have received growing attentions owing to their potential applications in the fields of chemical and synthetic biology. Here, we describe the development of reduction-responsive deoxyribonucleic acid (DNA) duplexes, in… read more here.
Keywords: reduction; responsive dna; reduction responsive; dna duplex ... See more keywords
Duplex DNA is Weakened in Nanoconfinement.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c01978
Abstract: For proteins and DNA secondary structures such as G-quadruplexes and i-motifs, nanoconfinement can facilitate their folding and increase structural stabilities. However, properties of physiologically prevalent B-DNA duplex have not been elucidated inside nanocavity. By using… read more here.
Keywords: dna; duplex; hairpin dna; dna hairpin ... See more keywords
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05406-y
Abstract: Type IIA topoisomerases (Top2s) manipulate the handedness of DNA crossovers by introducing a transient and protein-linked double-strand break in one DNA duplex, termed the DNA-gate, whose opening allows another DNA segment to be transported through… read more here.
Keywords: dna gate; dna passage; dna duplex; dna ... See more keywords
Exploring potentially alternative non-canonical DNA duplex structures through simulation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1483839
Abstract: Abstract Hopkins proposed an alternative and chirally distinct family of double-stranded DNA (dsDNA) models that have antiparallel chains with 5′→3′ senses opposite to those of the right-handed Watson–Crick (WC) family. Termed configuration II, this family… read more here.
Keywords: potentially alternative; dna; alternative non; exploring potentially ... See more keywords
Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1211
Abstract: Abstract This manuscript reports the molecular basis for double-stranded DNA (dsDNA) binding of hairpin polyamides incorporating a 5-alkyl thiazole (Nt) unit. Hairpin polyamides containing an N-terminal Nt unit induce higher melting stabilisation of target dsDNA… read more here.
Keywords: containing hairpin; basis; hairpin; hairpin polyamides ... See more keywords
The DNA Duplex as an Aqueous One-Dimensional Soft Crystal Scaffold for Photochemistry
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20180278
Abstract: In this account, we demonstrate that DNA duplex is an ideal scaffold for photochemistry, particularly for comparison of photochemical theory with experiments. The well-defined structure of a DNA du... read more here.
Keywords: duplex aqueous; dna; scaffold photochemistry; aqueous one ... See more keywords