Circularly polarized luminescence of helically assembled pyrene π-stacks on RNA and DNA duplexes.
Sign Up to like & getrecommendations! Published in 2018 at "Chirality"
DOI: 10.1002/chir.22838
Abstract: In this report, we describe the circularly polarized luminescence (CPL) of the RNA duplexes having one to four 2'-O-pyrene modified uridines (Upy) and the DNA duplexes having two, four, and six pyrene modified non-nucleosidic linkers… read more here.
Keywords: dna; dna duplexes; circularly polarized; pyrene modified ... See more keywords
Delocalization-Assisted Transport through Nucleic Acids in Molecular Junctions.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00072
Abstract: The flow of charge through molecules is central to the function of supramolecular machines, and charge transport in nucleic acids is implicated in molecular signaling and DNA repair. We examine the transport of electrons through… read more here.
Keywords: transport nucleic; nucleic acids; dna duplexes; transport ... See more keywords
Thermodynamic Stability of DNA Duplexes Comprising the Simplest T → dU Substitutions.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00676
Abstract: Members of the uracil-DNA glycosylase (UDG) enzyme family recognize and bind uracil, sequestering it within the binding site pocket and catalyzing the cleavage of the base from the deoxyribose, leaving an abasic site. The recognition… read more here.
Keywords: nearest neighbor; dna; dna duplexes; stability dna ... See more keywords
Thermostability Trends of TNA:DNA Duplexes Reveal Strong Purine Dependence.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.9b00028
Abstract: The development of high fidelity polymerases and streamlined synthesis of threose nucleic acid (TNA) triphosphates and phosphoramidites has made TNA accessible as a motif for generating nuclease-resistant high-affinity aptamers, antisense oligos, and synthetic genetic biopolymers.… read more here.
Keywords: dna duplexes; tna dna; purine content; dna ... See more keywords
Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10070
Abstract: DNA interstrand cross-links (ICLs) prevent DNA replication and transcription and can lead to potentially lethal events, such as cancer or bone marrow failure. ICLs are typically repaired by proteins within the Fanconi Anemia (FA) pathway,… read more here.
Keywords: cross links; dna; synthesis; dna duplexes ... See more keywords
Silver soldering of PNA:DNA duplexes: assembly of a triple duplex from bimodal PNAs with all-C on one face.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07297h
Abstract: DNA:bm-PNA duplexes endowed with all-C on either the t-amide or triazole face and mixed base sequence on the other face can be welded with silver ions through C:Ag+:C connects to give triple duplexes in one… read more here.
Keywords: soldering pna; dna; silver soldering; face ... See more keywords
The effects of a neutral cosolute on the B to Z transition for DNA duplexes incorporating both CG and CA steps
Sign Up to like & getrecommendations! Published in 2017 at "Nucleosides, Nucleotides and Nucleic Acids"
DOI: 10.1080/15257770.2017.1388395
Abstract: ABSTRACT In the cell, nearly 40% of the volume is occupied by macromolecular crowding agents and smaller osmolytes accumulate in response to environmental stresses. Of particular interest is the influence of osmolytes on the transition… read more here.
Keywords: effects neutral; transition; dna; dna duplexes ... See more keywords
Thienoguanosine brightness in DNA duplexes is governed by the localization of its ππ* excitation in the lowest energy absorption band
Sign Up to like & getrecommendations! Published in 2022 at "Methods and Applications in Fluorescence"
DOI: 10.1088/2050-6120/ac6ab6
Abstract: Thienoguanosine (thG) is an isomorphic fluorescent guanosine (G) surrogate, which almost perfectly mimics the natural G in DNA duplexes and may therefore be used to sensitively investigate for example protein-induced local conformational changes. To fully… read more here.
Keywords: band; thg; dna duplexes; energy absorption ... See more keywords
Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkaa1249
Abstract: We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (Tm) of PNA+DNA duplexes by approximately… read more here.
Keywords: nucleic acids; dna duplexes; peptide nucleic; dna ... See more keywords
Single-molecule analysis of i-motif within self-assembled DNA duplexes and nanocircles
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz565
Abstract: Abstract The cytosine (C)-rich sequences that can fold into tetraplex structures known as i-motif are prevalent in genomic DNA. Recent studies of i-motif–forming sequences have shown increasing evidence of their roles in gene regulation. However,… read more here.
Keywords: single molecule; dna; dna duplexes; assembled dna ... See more keywords
High-Energy Long-Lived Emitting Mixed Excitons in Homopolymeric Adenine-Thymine DNA Duplexes
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27113558
Abstract: The publication deals with polymeric pA●pT and oligomeric A20●T20 DNA duplexes whose fluorescence is studied by time-correlated single photon counting. It is shown that their emission on the nanosecond timescale is largely dominated by high-energy… read more here.
Keywords: high energy; long lived; energy; dna duplexes ... See more keywords