The Design and Application of DNA-Editing Enzymes as Base Editors.
Sign Up to like & getrecommendations! Published in 2023 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-052521-013938
Abstract: DNA-editing enzymes perform chemical reactions on DNA nucleobases. These reactions can change the genetic identity of the modified base or modulate gene expression. Interest in DNA-editing enzymes has burgeoned in recent years due to the… read more here.
Keywords: base editors; editing enzymes; design application; biochemistry ... See more keywords
MagnEdit—interacting factors that recruit DNA-editing enzymes to single base targets
Sign Up to like & getrecommendations! Published in 2020 at "Life Science Alliance"
DOI: 10.26508/lsa.201900606
Abstract: This study reports a new, non-covalent strategy—called MagnEdit—that attracts the DNA cytosine deaminase APOBEC3B to a Cas9-directed site for C-to-T editing. Although CRISPR/Cas9 technology has created a renaissance in genome engineering, particularly for gene knockout… read more here.
Keywords: magnedit interacting; dna editing; base; single base ... See more keywords
Evolutionary Comparative Analyses of DNA-Editing Enzymes of the Immune System: From 5-Dimensional Description of Protein Structures to Immunological Insights and Applications to Protein Engineering
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.642343
Abstract: The immune system is unique among all biological sub-systems in its usage of DNA-editing enzymes to introduce targeted gene mutations and double-strand DNA breaks to diversify antigen receptor genes and combat viral infections. These processes,… read more here.
Keywords: editing enzymes; dna editing; immune system; evolutionary comparative ... See more keywords