LAUSR

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.

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1 Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.08.008

Abstract: DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutières… read more here.

Keywords: end resection; dna end; repair; samhd1 ... See more keywords

Control of DNA end resection by yeast Hmo1p affects efficiency of DNA end-joining.

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1 Published in 2017 at "DNA repair"

DOI: 10.1016/j.dnarep.2017.03.002

Abstract: The primary pathways for DNA double strand break (DSB) repair are homologous recombination (HR) and non-homologous end-joining (NHEJ). The choice between HR and NHEJ is influenced by the extent of DNA end resection, as extensive… read more here.

Keywords: end joining; end resection; end; dna end ... See more keywords

Regulatory control of DNA end resection by Sae2 phosphorylation

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1 Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-06417-5

Abstract: DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and are instead channeled to homology-directed repair. Using biochemical, genetic, and imaging methods,… read more here.

Keywords: sae2; end resection; end; dna end ... See more keywords

Mre11-Rad50: the DNA end game.

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2 Published in 2023 at "Biochemical Society transactions"

DOI: 10.1042/bst20220754

Abstract: The Mre11-Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair of DNA double-strand breaks and other DNA termini in all kingdoms of life. It is an intricate DNA associated molecular machine that cuts, among… read more here.

Keywords: dna; mre11 rad50; dna end;

Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system

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1 Published in 2020 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaa094

Abstract: Abstract During non-homologous DNA end joining (NHEJ), bringing two broken dsDNA ends into proximity is an essential prerequisite for ligation by XRCC4:Ligase IV (X4L4). This physical juxtaposition of DNA ends is called NHEJ synapsis. In… read more here.

Keywords: homologous dna; end joining; synapsis; dna end ... See more keywords

SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining

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1 Published in 2021 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkab051

Abstract: Abstract Aberrant end joining of DNA double strand breaks leads to chromosomal rearrangements and to insertion of nuclear or mitochondrial DNA into breakpoints, which is commonly observed in cancer cells and constitutes a major threat… read more here.

Keywords: end joining; end; samhd1 restrains; dna end ... See more keywords

NBS1-CtIP–mediated DNA end resection suppresses cGAS binding to micronuclei

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2 Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac079

Abstract: Abstract Cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) is activated in cells with defective DNA damage repair and signaling (DDR) factors, but a direct role for DDR factors in regulating cGAS activation in response to micronuclear… read more here.

Keywords: dna; ctip; dna end; cgas binding ... See more keywords

C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties

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1 Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21186725

Abstract: The Ku70/80 heterodimer binds to DNA ends and attracts other proteins involved in the non-homologous end-joining (NHEJ) pathway of DNA double-strand break repair. We developed a novel assay to measure DNA binding and release kinetics… read more here.

Keywords: dna; end; dna ends; terminal extensions ... See more keywords