How chromosome topologies get their shape: views from proximity ligation and microscopy methods
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13961
Abstract: The 3D organization of our genome is an important determinant for the transcriptional output of a gene in (patho)physiological contexts. The spatial organization of linear chromosomes within nucleus is dominantly inferred using two distinct approaches,… read more here.
Keywords: proximity ligation; microscopy; ligation; dna fish ... See more keywords
Abstract 176: Simultaneous spatial characterisation of copy number change and immune cell profiling using DNA FISH and multiplexed immunofluorescence
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-176
Abstract: Recent advances in spatial characterization of protein expression has greatly improved our understanding of tissue architecture, cell-cell interactions and their function. In this work, we aim to further improve cell characterization by combining the detection… read more here.
Keywords: protein; immune cell; dna fish; copy number ... See more keywords