LAUSR

DNA Framework‐Enabled 3D Organization of Antiarrhythmic Drugs for Radiofrequency Catheter Ablation

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0 Published in 2024 at "Advanced Materials"

DOI: 10.1002/adma.202401960

Abstract: Preorganizing molecular drugs within a microenvironment is crucial for the development of efficient and controllable therapeutic systems. Here, the use of tetrahedral DNA framework (TDF) is reported to preorganize antiarrhythmic drugs (herein doxorubicin, Dox) in… read more here.

Keywords: ablation; dox; dna framework; catheter ablation ... See more keywords

Interfacial DNA Framework-Enhanced Background-to-Signal Transition for Ultrasensitive and Specific Micro-RNA Detection.

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0 Published in 2022 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.2c03075

Abstract: Interfacial DNA self-assembly is fundamental to solid nucleic acid biosensors, whereas how to improve the signal-to-noise ratio has always been a challenge, especially in the charge-based electrochemical DNA sensors because of the large noise from… read more here.

Keywords: signal transition; detection; dna framework; dna ... See more keywords

Artificial DNA Framework Channel Modulates Antiapoptotic Behavior in Ischemia-Stressed Cells via Destabilizing Promoter G-Quadruplex.

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0 Published in 2024 at "ACS nano"

DOI: 10.1021/acsnano.3c06563

Abstract: Regulating folding/unfolding of gene promoter G-quadruplexes (G4s) is important for understanding the topological changes in genomic DNAs and the biological effects of such changes on important cellular events. Although many G4-stabilizing ligands have been screened… read more here.

Keywords: ischemia stressed; framework channel; promoter; gene ... See more keywords

DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity.

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2 Published in 2023 at "Chemical communications"

DOI: 10.1039/d2cc05763h

Abstract: We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against… read more here.

Keywords: cytotoxicity; drug patterns; dna framework; framework carriers ... See more keywords

Tetrahedral DNA Framework-Programmed Electrochemical Biosenors with Gold Nanoparticles for Ultrasensitive Cell-Free DNA Detection

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1 Published in 2022 at "Nanomaterials"

DOI: 10.3390/nano12040666

Abstract: Tumor-associated cell-free DNA (cfDNA) is a dynamic biomarker for genetic analysis, early diagnosis and clinical treatment of cancers. However, its detection has limitations because of its low abundance in blood or other complex bodily fluids.… read more here.

Keywords: dna; cell free; dna framework; detection ... See more keywords