Base excision-initiated terminal deoxynucleotide transferase-assisted amplification for simultaneous detection of multiple DNA glycosylases
Sign Up to like & getrecommendations! Published in 2022 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-022-03978-9
Abstract: Various DNA glycosylases involved in base excision repair may be associated with a wide disease spectrum that includes cancer, myocardial infarction, neurodegenerative disorders, etc. In this paper, we developed a sensitive method for simultaneous detection… read more here.
Keywords: dna; amplification; detection; dna glycosylases ... See more keywords
Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167334
Abstract: Base excision DNA repair (BER) is necessary for removal of damaged nucleobases from the genome and their replacement with normal nucleobases. BER is initiated by DNA glycosylases, the enzymes that cleave the N-glycosidic bonds of… read more here.
Keywords: hneil2; dna; exchange mass; hydrogen deuterium ... See more keywords
Combination of bidirectional strand displacement amplification with single-molecule detection for multiplexed DNA glycosylases assay.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2021.122805
Abstract: DNA glycosylases can initiate base excision repair pathway to repair endogenous DNA base damages for the maintenance of genome stability. Multiple DNA glycosylases exhibit abnormal in various diseases, and the simultaneous measurement of different DNA… read more here.
Keywords: molecule detection; single molecule; dna glycosylases; dna ... See more keywords
Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2019.04.006
Abstract: The base excision repair (BER) pathway historically has been associated with maintaining genome integrity by eliminating nucleobases with small chemical modifications. In the past several years, however, BER was found to play additional roles in… read more here.
Keywords: base excision; emerging roles; excision repair; dna glycosylases ... See more keywords
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04472-4
Abstract: Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first… read more here.
Keywords: dna; mutation frequencies; cancer; neil1 neil2 ... See more keywords
Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21239226
Abstract: Cancer is the second leading cause of death with tens of millions of people diagnosed with cancer every year around the world. Most radio- and chemotherapies aim to eliminate cancer cells, notably by causing severe… read more here.
Keywords: drug targets; anticancer drug; dna glycosylases; cancer ... See more keywords