Rational design and characterization of a DNA/HDAC dual-targeting inhibitor containing nitrogen mustard and 2-aminobenzamide moieties.
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DOI: 10.1039/c7md00476a
Abstract: Histone deacetylases (HDACs) play a key role not only in gene expression but also in DNA repair. Herein, we report the rational design and characterization of a compound named chlordinaline containing nitrogen mustard and 2-aminobenzamide… read more here.
Keywords: mustard aminobenzamide; dual targeting; dna hdac; nitrogen mustard ... See more keywords