Extracellular Trap-Mimicking DNA-Histone Mesostructures Synergistically Activate Dendritic Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900926
Abstract: Extracellular traps (ETs), such as neutrophil extracellular traps, are a physical mesh deployed by immune cells to entrap and constrain pathogens. ETs are immunogenic structures composed of DNA, histones, and an array of variable protein… read more here.
Keywords: extracellular trap; dna; dna histone; dendritic cells ... See more keywords
A Nitrogen Mustard Induces Formation of DNA-Histone Cross-Links in Nucleosome Core Particles.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00354
Abstract: Nitrogen mustards have long been used in cancer chemotherapy, and their cytotoxicity has traditionally been attributed to the formation of DNA interstrand cross-links and DNA monoalkylation. Recent studies have shown that exposure to nitrogen mustards… read more here.
Keywords: cross links; formation; cross; histone cross ... See more keywords
DNA and Histone Methylation Regulates Different Types of Fruit Ripening by Transcriptome and Proteome Analyses.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c06391
Abstract: Methylation affects different aspects of genetic material stability, gene expression regulation, and histone modification. The previous reports depicted that DNA and histone methylation regulates plant growth and development. In this study, we evaluated the effects… read more here.
Keywords: methylation; fruit ripening; expression; histone methylation ... See more keywords
Nanopore Sensing of DNA-Histone Complexes on Nucleosome Arrays.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c01865
Abstract: The location of nucleosomes in DNA and their structural stability are critical in regulating DNA compaction, site accessibility, and epigenetic gene regulation. Here, we combine the nanopore platform-based fast and label-free single-molecule detection technique with… read more here.
Keywords: dna; nanopore sensing; sensing dna; voltage dependent ... See more keywords
METHIONINE SYNTHASE1 Is Involved in Chromatin Silencing by Maintaining DNA and Histone Methylation1.
Sign Up to like & getrecommendations! Published in 2019 at "Plant physiology"
DOI: 10.1104/pp.19.00528
Abstract: DNA methylation and histone modification are important epigenetic marks that coregulate gene expression and genome stability. To identify factors involved in chromatin silencing, we carried out a forward genetic screen for mutants that release the… read more here.
Keywords: dna; methionine; chromatin silencing; involved chromatin ... See more keywords
Post‐cardiac arrest level of free‐plasma DNA and DNA‐histone complexes
Sign Up to like & getrecommendations! Published in 2017 at "Acta Anaesthesiologica Scandinavica"
DOI: 10.1111/aas.12882
Abstract: Plasma DNA‐histone complexes and total free‐plasma DNA have the potential to quantify the ischaemia‐reperfusion damages occurring after cardiac arrest. Furthermore, DNA‐histone complexes may have the potential of being a target for future treatment. The aim… read more here.
Keywords: histone complexes; plasma dna; dna histone; dna ... See more keywords
Changes in cell differentiation and proliferation lead to production of abzymes in EAE mice treated with DNA–Histone complexes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13850
Abstract: Experimental autoimmune encephalomyelitis (EAE)‐prone C57BL/6 mice are used as a model of human multiple sclerosis. We immunize mice with myelin oligodendrocyte glycoprotein (MOG), DNA–histone and DNA‐methylated bovine serum albumin (met‐BSA) complexes to reveal different characteristics… read more here.
Keywords: dna; mog dna; histone complexes; mice ... See more keywords
In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-06-722298
Abstract: NETosis is a physiologic process in which neutrophils release their nuclear material in the form of neutrophil extracellular traps (NETs). NETs have been reported to directly promote thrombosis in animal models. Although the effects of… read more here.
Keywords: neutrophil extracellular; histone proteins; dna; extracellular traps ... See more keywords
DNA-Histone Cross-Links: Formation and Repair
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.607045
Abstract: The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the stable organization of nucleosome core particles, and for the folding… read more here.
Keywords: histone cross; repair; dna histone; dna ... See more keywords
The Role of DNA/Histone Modifying Enzymes and Chromatin Remodeling Complexes in Testicular Germ Cell Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Cancers"
DOI: 10.3390/cancers11010006
Abstract: It is well established that cancer cells exhibit alterations in chromatin structure and accessibility. Indeed, the dysregulation of many protein-coding players with enzymatic activity (DNA and histone-modifying enzymes) and chromatin remodelers have been depicted in… read more here.
Keywords: enzymes chromatin; dna; histone modifying; modifying enzymes ... See more keywords
Visualization of Nuclease- and Serum-Mediated Chromatin Degradation with DNA–Histone Mesostructures
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043222
Abstract: This study analyzed the nuclease- and serum-driven degradation of millimeter-scale, circular DNA–histone mesostructures (DHMs). DHMs are bioengineered chromatin meshes of defined DNA and histone compositions designed as minimal mimetics of physiological extracellular chromatin structures, such… read more here.
Keywords: serum mediated; serum; nuclease serum; histone mesostructures ... See more keywords