RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.04.025
Abstract: Summary R-loops comprise an RNA/DNA hybrid and displaced single-stranded DNA. They play important biological roles and are implicated in pathology. Even so, proteins recognizing these structures are largely undefined. Using affinity purification with the S9.6… read more here.
Keywords: dna; rna dna; dna hybrid; biology ... See more keywords
RNA-DNA hybrid nanoshapes that self-assemble dependent on ligand binding.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/c9nr09706f
Abstract: Self-assembly of nucleic acid nanostructures is driven by selective association of oligonucleotide modules through base pairing between complementary sequences. Herein, we report the development of RNA-DNA hybrid nanoshapes that conditionally assemble under the control of… read more here.
Keywords: dna; nanoshapes self; rna dna; self assemble ... See more keywords
RNA–DNA hybrid nano-materials for highly efficient and long lasting RNA interference effect
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra06249f
Abstract: In attempts to effectively improve RNAi function, we herein report a new RNAi approach using X-shaped RDNA and Dgel (RNA interfering DNA hydrogel, Ri-Dgel). X-shaped RDNA is a 4 branched nanostructure which was composed of… read more here.
Keywords: rna dna; rnai; dgel; dna hybrid ... See more keywords
Construction of "peptide-hemin/DNA" hybrid-complexes and their peroxidase activities
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Communications"
DOI: 10.1039/d3cc00752a
Abstract: N-Acetylated microperoxidase-11 and G-quadruplex DNA are shown to form a stable "peptide-hemin/DNA" hybrid-complex, in which the peroxidase activity at the interface between hemin and the G-quartet planes exponentially increases with increasing Ka value. read more here.
Keywords: hemin dna; dna; peptide hemin; hemin ... See more keywords
Spontaneous Embedding of DNA Mismatches Within the RNA:DNA Hybrid of CRISPR-Cas9
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.00039
Abstract: CRISPR-Cas9 is the forefront technology for editing the genome. In this system, the Cas9 protein is programmed with guide RNAs to process DNA sequences that match the guide RNA forming an RNA:DNA hybrid structure. However,… read more here.
Keywords: dna; crispr cas9; rna dna; mismatches within ... See more keywords