A Responsive DNA Hydrogel Containing Poly‐Aptamers as Dual‐Target Inhibitors for Localized Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202401563
Abstract: Immune checkpoint blockade (ICB) is emerging as an efficient strategy for cancer immunotherapy, which highly relies on the controlled loading and release of immune checkpoints inhibitors. Herein, a responsive DNA hydrogel containing polyvalent aptamers as… read more here.
Keywords: responsive dna; cancer immunotherapy; dna hydrogel; dna ... See more keywords
Retardation of Antigen Release from DNA Hydrogel Using Cholesterol‐Modified DNA for Increased Antigen‐Specific Immune Response
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201700355
Abstract: Our previous study indicates that cationization of an antigen is effective for sustained release of both immunostimulatory DNA containing unmethylated cytosine-phosphate-guanine (CpG) dinucleotides, or CpG DNA, and antigen from a DNA hydrogel. Another approach to… read more here.
Keywords: cholesterol modified; dna; dna hydrogel; antigen ... See more keywords
Constructing Immunomodulator Biosynthesis Factory in Grafting‐From DNA Hydrogel for Heart Valve Regeneration
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202506728
Abstract: The development of heart valve prostheses with regenerative capabilities offers significant potential to overcome the limitations of existing commercial artificial valves in clinical practice. Immune modulation plays a crucial role in heart valve regeneration by… read more here.
Keywords: heart valve; heart; regeneration; biosynthesis factory ... See more keywords
Thermal-Responsive MXene-DNA Hydrogel for Near-Infrared Light Triggered Localized Photothermal-Chemo Synergistic Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200263
Abstract: Stimuli-responsive DNA hydrogels are promising candidates for cancer treatment, as they not only possess biocompatible and biodegradable 3D network structures as highly efficient carriers for therapeutic agents but also are capable of undergoing programmable gel-to-solution… read more here.
Keywords: dna; mxene dna; dna hydrogel; cancer therapy ... See more keywords
Programmable DNA Hydrogel Provides Suitable Microenvironment for Enhancing TSPCS Therapy in Healing of Tendinopathy.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207231
Abstract: Tendon stem/progenitor cells (TSPCs) therapy is a promising strategy for enhancing cell matrix and collagen synthesis, and regulating the metabolism of the tendon microenvironment during tendon injury repair. Nevertheless, the barren microenvironment and gliding shear… read more here.
Keywords: dna; microenvironment; therapy; dna hydrogel ... See more keywords
An Affinity-enhanced DNA Intercalator with Intense ECL Embedded in DNA Hydrogel for Biosensing Applications.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c00152
Abstract: Herein, an amphiphilic perylene derivative (denoted as PTC-DEDA) was explored as DNA intercalators endowed with an enhanced affinity and intense electrochemiluminescence (ECL) to construct a target-induced DNA hydrogel biosensing platform for the sensitive detection of… read more here.
Keywords: affinity; hydrogel biosensing; dna; dna hydrogel ... See more keywords
CRISPR/Cas13a-Responsive and RNA-Bridged DNA Hydrogel Capillary Sensor for Point-of-Care Detection of RNA
Sign Up to like & getrecommendations! Published in 2024 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.4c02087
Abstract: Disease diagnostics and surveillance increasingly highlight the importance of portable, cost-effective, and sensitive point-of-care (POC) detection of nucleic acids. Here, we report a CRISPR/Cas13a-responsive and RNA-bridged DNA hydrogel capillary sensor for the direct and visual… read more here.
Keywords: detection; crispr cas13a; hydrogel; rna ... See more keywords
Integrating Metal-Organic Framework Hybrid into Nucleic Acid-Based Hydrogel for Highly Selective Recognition and Sensitive Detection of Sarafloxacin.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c05180
Abstract: Metal-organic framework-based hybrids (MOFzyme) have promising applications in colorimetric aptasensors due to their highly efficient and stable catalytic activity. However, their efficient application in biosensors remains a challenging issue due to the limited reaction site… read more here.
Keywords: detection; hydrogel; organic framework; metal organic ... See more keywords
Homogeneous Entropy Catalytic-Driven DNA Hydrogel as Strong Signal Blocker for Highly Sensitive Electrochemical Detection of Platelet-Derived Growth Factor.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01766
Abstract: In this work, an elegantly designed electrochemical biosensor was constructed for platelet-derived growth factor (PDGF) detection based on homogeneous entropy catalytic-induced DNA hydrogel as a strong signal blocker to significantly inhibit the electrochemical signal of… read more here.
Keywords: detection; entropy catalytic; blocker; dna hydrogel ... See more keywords
A fluorescent DNA hydrogel aptasensor based on the self-assembling of rolling circle amplification products for sensitive detection of OTA.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b06021
Abstract: A sensitive fluorescent DNA hydrogel aptasensor based on the self-assembling of rolling circle amplification (RCA) products was developed for Ochratoxin A (OTA) detection in beer. A competitive binding mode of aptamer, complementary sequence and target… read more here.
Keywords: dna hydrogel; fluorescent dna; hydrogel; hydrogel aptasensor ... See more keywords
Constructing Stiffness Tunable DNA Hydrogels Based on DNA Modules with Adjustable Rigidity.
Sign Up to like & getrecommendations! Published in 2024 at "Nano letters"
DOI: 10.1021/acs.nanolett.4c01870
Abstract: DNA hydrogel represents a potent material for crafting biological scaffolds, but the toolbox to systematically regulate the mechanical property is still limited. Herein, we have provided a strategy to tune the stiffness of DNA hydrogel… read more here.
Keywords: constructing stiffness; rigidity; dna; dna hydrogel ... See more keywords