Retardation of Antigen Release from DNA Hydrogel Using Cholesterol‐Modified DNA for Increased Antigen‐Specific Immune Response
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201700355
Abstract: Our previous study indicates that cationization of an antigen is effective for sustained release of both immunostimulatory DNA containing unmethylated cytosine-phosphate-guanine (CpG) dinucleotides, or CpG DNA, and antigen from a DNA hydrogel. Another approach to… read more here.
Keywords: cholesterol modified; dna; dna hydrogel; antigen ... See more keywords
Thermal-Responsive MXene-DNA Hydrogel for Near-Infrared Light Triggered Localized Photothermal-Chemo Synergistic Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200263
Abstract: Stimuli-responsive DNA hydrogels are promising candidates for cancer treatment, as they not only possess biocompatible and biodegradable 3D network structures as highly efficient carriers for therapeutic agents but also are capable of undergoing programmable gel-to-solution… read more here.
Keywords: dna; mxene dna; dna hydrogel; cancer therapy ... See more keywords
Programmable DNA Hydrogel Provides Suitable Microenvironment for Enhancing TSPCS Therapy in Healing of Tendinopathy.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207231
Abstract: Tendon stem/progenitor cells (TSPCs) therapy is a promising strategy for enhancing cell matrix and collagen synthesis, and regulating the metabolism of the tendon microenvironment during tendon injury repair. Nevertheless, the barren microenvironment and gliding shear… read more here.
Keywords: dna; microenvironment; therapy; dna hydrogel ... See more keywords
An Affinity-enhanced DNA Intercalator with Intense ECL Embedded in DNA Hydrogel for Biosensing Applications.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c00152
Abstract: Herein, an amphiphilic perylene derivative (denoted as PTC-DEDA) was explored as DNA intercalators endowed with an enhanced affinity and intense electrochemiluminescence (ECL) to construct a target-induced DNA hydrogel biosensing platform for the sensitive detection of… read more here.
Keywords: affinity; hydrogel biosensing; dna; dna hydrogel ... See more keywords
Homogeneous Entropy Catalytic-Driven DNA Hydrogel as Strong Signal Blocker for Highly Sensitive Electrochemical Detection of Platelet-Derived Growth Factor.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01766
Abstract: In this work, an elegantly designed electrochemical biosensor was constructed for platelet-derived growth factor (PDGF) detection based on homogeneous entropy catalytic-induced DNA hydrogel as a strong signal blocker to significantly inhibit the electrochemical signal of… read more here.
Keywords: detection; entropy catalytic; blocker; dna hydrogel ... See more keywords
A fluorescent DNA hydrogel aptasensor based on the self-assembling of rolling circle amplification products for sensitive detection of OTA.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b06021
Abstract: A sensitive fluorescent DNA hydrogel aptasensor based on the self-assembling of rolling circle amplification (RCA) products was developed for Ochratoxin A (OTA) detection in beer. A competitive binding mode of aptamer, complementary sequence and target… read more here.
Keywords: dna hydrogel; fluorescent dna; hydrogel; hydrogel aptasensor ... See more keywords
Self-Assembly of Dendritic DNA into a Hydrogel: Application in Three-Dimensional Cell Culture.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c14445
Abstract: With inherent biocompatibility, biodegradability, and unique programmability, hydrogels with a DNA framework show great potential in three-dimensional (3D) cell culture. Here, a DNA hydrogel was assembled by a dendritic DNA with four branches. The hydrogel… read more here.
Keywords: dna hydrogel; cell culture; cell; dna ... See more keywords
Physically Cross-Linked DNA Hydrogel-Based Sustained Cytokine Delivery for In Situ Diabetic Alveolar Bone Rebuilding.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c04769
Abstract: The development of a biodegradable and shape-adaptable bioscaffold that can enhance local cytokine retention and bioactivity is essential for the application of immunotherapy in periodontal diseases. Here, we report a biodegradable, anti-inflammatory, and osteogenic ILGel… read more here.
Keywords: dna hydrogel; bone; diabetic alveolar; alveolar bone ... See more keywords
Distance-Based Biosensor for Ultrasensitive Detection of Uracil-DNA Glycosylase Using Membrane Filtration of DNA Hydrogel.
Sign Up to like & getrecommendations! Published in 2021 at "ACS sensors"
DOI: 10.1021/acssensors.1c00624
Abstract: In the deoxyribonucleic acid (DNA) repair pathways, DNA repair enzymes have great significance for genomic integrity. As one important initiator of the base-excision repair pathway, the aberrant activity of uracil-DNA glycosylase (UDG) is closely associated… read more here.
Keywords: uracil dna; detection; dna; distance ... See more keywords
Acid-Resistant and Physiological pH-Responsive DNA Hydrogel Composed of A-Motif and i-Motif toward Oral Insulin Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13426
Abstract: An acid-resistant DNA hydrogel that is stable in an extremely acidic environment with pH as low as 1.2 has not been reported before, largely due to the instability of DNA-hybridized structures. To achieve this, adenine… read more here.
Keywords: dna hydrogel; delivery; dna; acid resistant ... See more keywords
Amplified impedimetric aptasensor combining target-induced DNA hydrogel formation with pH-stimulated signal amplification for the heparanase assay.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c6nr08353f
Abstract: Herein, a novel electrochemical impedimetric biosensor for the heparanase (HPA) assay was developed based on target protein-induced DNA hydrogel formation, followed by pH-stimulation of the hydrogel density to increase the signal amplification. The method involved… read more here.
Keywords: hydrogel; dna; formation; induced dna ... See more keywords