Sensitive detection of hydroxymethylcytosine levels in normal and neoplastic cells and tissues
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800523
Abstract: A new sensitive analytical method using capillary electrophoresis with laser induced fluorescence (CE‐LIF) was applied for the simultaneous detection of DNA methylation and hydroxymethylation levels in human cancers of different origin. DNA hydroxymethylation, measured as… read more here.
Keywords: detection; 5hmc levels; detection hydroxymethylcytosine; hydroxymethylation ... See more keywords
DNA hydroxymethylation of colorectal primary carcinoma and its association with survival
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.24978
Abstract: A total of 71 cases of colorectal carcinoma with hepatic metastasis were enrolled from the Department of Pathology of SIR RUN RUN SHAW Hospital. Paired primary tumors, hepatic metastases, and normal mucosa samples were collected… read more here.
Keywords: primary carcinoma; carcinoma; hydroxymethylation; dna hydroxymethylation ... See more keywords
Vitamin C Promotes Astrocyte Differentiation Through DNA Hydroxymethylation
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2886
Abstract: Previous studies have reported that vitamin C (VC) promotes neural stem/precursor cell (NSC) differentiation toward dopamine (DA) neurons via DNA hydroxymethylation‐induced transcriptional activation of DA neuron‐specific genes. To further understand the VC effects on NSC… read more here.
Keywords: promotes astrocyte; vitamin promotes; differentiation; dna hydroxymethylation ... See more keywords
Analysis of DNA Hydroxymethylation Using Colorimetric Assay.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4899-7708-3_8
Abstract: Hydroxymethylcytosine (hmC or 5-hmC) is a nitrogen base occurring as a result of cytosine methylation followed by replacing a methyl group with a hydroxyl group through active oxidation. 5-hmC is considered to be one of… read more here.
Keywords: analysis dna; hydroxymethylation using; dna; using colorimetric ... See more keywords
Variation in global DNA hydroxymethylation with age associated with schizophrenia
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2017.08.022
Abstract: To improve understanding of DNA hydroxymethylation (5hmC) and methylation (5mC) in the development of schizophrenia, this study examined global 5hmC and 5mC levels in peripheral blood DNA of 264 patients with schizophrenia and 221 controls… read more here.
Keywords: global dna; age; dna hydroxymethylation; variation global ... See more keywords
TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23735-3
Abstract: The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and… read more here.
Keywords: tet1; myelin repair; dna hydroxymethylation;
Epigenetic biomarkers of cold and heat syndromes of rheumatoid arthritis: Combining DNA hydroxymethylation and mRNA‐sequencing
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.14480
Abstract: Syndrome (Zheng in Mandarin Chinese) is the induction of disease attributes in the theory of traditional Chinese medicine (TCM). This is often used to explain why patients with the same disease show different symptoms. Cold… read more here.
Keywords: epigenetic biomarkers; hydroxymethylation; cold heat; heat syndromes ... See more keywords
Developmental Iron Deficiency Dysregulates TET Activity and DNA Hydroxymethylation in the Rat Hippocampus and Cerebellum
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neuroscience"
DOI: 10.1159/000521704
Abstract: Iron deficiency (ID) during neurodevelopment is associated with lasting cognitive and socioemotional deficits and increased risk for neuropsychiatric disease throughout the lifespan. These neurophenotypical changes are underlain by gene dysregulation in the brain that outlasts… read more here.
Keywords: dna hydroxymethylation; iron; tet activity; dna ... See more keywords
Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Health Perspectives"
DOI: 10.1289/ehp5862
Abstract: Background: Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted… read more here.
Keywords: dna hydroxymethylation; cancer; hydroxymethylation; proliferation ... See more keywords
DNA Hydroxymethylation in Smoking-Associated Cancers
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052657
Abstract: 5-hydroxymethylcytosine (5-hmC) was first detected in mammalian DNA five decades ago. However, it did not take center stage in the field of epigenetics until 2009, when ten-eleven translocation 1 (TET1) was found to oxidize 5-methylcytosine… read more here.
Keywords: hydroxymethylation smoking; smoking associated; hydroxymethylation; hmc ... See more keywords
TET2 is involved in DNA hydroxymethylation, cell proliferation and inflammatory response in keratinocytes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.10989
Abstract: DNA methylation and hydroxymethylation are the most common epigenetic modifications associated with the cell cycle and the inflammatory response. The present study aimed to investigate the role of 5-hydroxymethyl-cytosine (5-hmC) and ten-eleven translocation-2 (TET2) in… read more here.
Keywords: hydroxymethylation; cell; dna hydroxymethylation; inflammatory response ... See more keywords