Realgar (α-As4S4) Treats Myelodysplasic Syndromes through Reducing DNA Hypermethylation
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-020-3263-8
Abstract: DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes (MDS). Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes, inducing gene silencing. Realgar (α-As4S4)… read more here.
Keywords: realgar; medicine; realgar as4s4; dna hypermethylation ... See more keywords
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
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DOI: 10.1038/nature24294
Abstract: The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely… read more here.
Keywords: idhmut; bcat1; dna hypermethylation; stem ... See more keywords
DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation
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DOI: 10.1038/s41477-020-0710-7
Abstract: The DNA methyltransferases MET1 and CMT3 are known to be responsible for maintenance of DNA methylation at symmetric CG and CHG sites, respectively, in Arabidopsis thaliana . However, it is unknown how the expression of… read more here.
Keywords: dream; methylation; maintenance; dna hypermethylation ... See more keywords
Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis
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DOI: 10.1080/1354750x.2018.1427795
Abstract: Abstract Context: Presbycusis, an age-related hearing impairment (ARHI), represents the most common sensory disability in adults. Today, the molecular mechanisms underlying presbycusis remain unclear. This is in particular due to the fact that ARHI is… read more here.
Keywords: p2rx2 kcnq5; kcnq5 erbb3; women presbycusis; erbb3 socs3 ... See more keywords
Age-associated global DNA hypermethylation augments the sensitivity of hearts towards ischemia-reperfusion injury
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DOI: 10.3389/fgene.2022.995887
Abstract: Most pre-clinical studies in cardiac ischemia-reperfusion injury (I/R) are carried out in young or old animals, which does not cater to the adult age in humans who encounter I/R. Not many studies in the literature… read more here.
Keywords: adult; age; global dna; injury ... See more keywords
SUMO1-modified DNA methyltransferase 1 induces DNA hypermethylation of VWC2 in the development of colorectal cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Neoplasma"
DOI: 10.4149/neo_2022_220817n841
Abstract: Aberrant DNA methylation of genes is closely linked to many aspects of tumor development. This study focuses on the effect of DNA hypermethylation of von Willebrand factor C domain containing 2 (VWC2) on colorectal cancer… read more here.
Keywords: dna; development; dna hypermethylation; cancer ... See more keywords