DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06771-4
Abstract: Oncolytic virotherapy is a promising therapeutic strategy that uses replication-competent viruses to selectively destroy malignancies. However, the therapeutic effect of certain oncolytic viruses (OVs) varies among cancer patients. Thus, it is necessary to overcome resistance… read more here.
Keywords: cancer; dna inhibition; antiviral response; dna ... See more keywords
Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response
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DOI: 10.18632/oncotarget.15062
Abstract: During DNA double strand breaks (DSBs) repair, coordinated activation of phosphatidylinositol 3-kinase (PI3K)-like kinases can activate p53 signaling pathway. Recent findings have identified novel interplays among these kinases demonstrating amplified first p53 pulses under DNA-PK… read more here.
Keywords: amplified p53; inhibition; dna inhibition; p53 responses ... See more keywords