The Presence of Human Papillomavirus DNA Integration is Associated with Poor Clinical Results in Patients with Third-Stage Cervical Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04654-2
Abstract: The presence of virus DNA integration into the cell genome was studied for 47 primary HPV16-positive patients with morphologically verified stage III cervical cancer. By using ROC analysis, the patients were divided into two groups:… read more here.
Keywords: dna integration; cervical cancer; integration; presence ... See more keywords
Integration of diverse DNA substrates by a casposase can be targeted to R-loops in vitro by its fusion to Cas9
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20203595
Abstract: Abstract CRISPR systems build adaptive immunity against mobile genetic elements by DNA capture and integration catalysed by Cas1–Cas2 protein complexes. Recent studies suggested that CRISPR repeats and adaptation module originated from a novel type of… read more here.
Keywords: dna integration; casposase; dna; fusion ... See more keywords
Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.02007-17
Abstract: ABSTRACT Chronic infection by hepatitis B virus (HBV) is the major contributor to liver disease worldwide. Though HBV replicates via a nuclear episomal DNA (covalently closed circular DNA [cccDNA]), integration of HBV DNA into the… read more here.
Keywords: dna integration; integration; dna; infection ... See more keywords
Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B
Sign Up to like & getrecommendations! Published in 2020 at "Gut"
DOI: 10.1136/gutjnl-2020-323300
Abstract: Objective The involvement of HBV DNA integration in promoting hepatocarcinogenesis and the extent to which the intrahepatic HBV reservoir modulates liver disease progression remains poorly understood. We examined the intrahepatic HBV reservoir, the occurrence of… read more here.
Keywords: dna integration; hbv dna; hbv reservoir; hbv ... See more keywords
Whole-genome resequencing using next-generation and Nanopore sequencing for molecular characterization of T-DNA integration in transgenic poplar 741
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-07625-y
Abstract: Background The molecular characterization information of T-DNA integration is not only required by public risk assessors and regulators, but is also closely related to the expression of exogenous and endogenous genes. At present, with the… read more here.
Keywords: dna integration; molecular characterization; poplar 741; dna ... See more keywords
HBV-human DNA integration in non-hepatic tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e13544
Abstract: e13544Background: Hepatitis B virus (HBV) infection in hepatocytes may induce chronic liver damage, which further leads to hepatocellular carcinoma. HBV infection was also reported in other cell ty... read more here.
Keywords: dna integration; hepatic tumors; hbv human; human dna ... See more keywords
Characterization of T-Circles and Their Formation Reveal Similarities to Agrobacterium T-DNA Integration Patterns
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.849930
Abstract: Agrobacterium transfers T-DNA to plants where it may integrate into the genome. Non-homologous end-joining (NHEJ) has been invoked as the mechanism of T-DNA integration, but the role of various NHEJ proteins remains controversial. Genetic evidence… read more here.
Keywords: characterization circles; dna integration; dna; circles formation ... See more keywords
DNA Double-Strand Break Repairs and Their Application in Plant DNA Integration
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13020322
Abstract: Double-strand breaks (DSBs) are considered to be one of the most harmful and mutagenic forms of DNA damage. They are highly toxic if unrepaired, and can cause genome rearrangements and even cell death. Cells employ… read more here.
Keywords: dna; dna double; double strand; dna integration ... See more keywords
Cellular Genomic Sites of Hepatitis B Virus DNA Integration
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.3390/genes9070365
Abstract: Infection with the Hepatitis B Virus (HBV) is one of the strongest risk-factors for liver cancer (hepatocellular carcinoma, HCC). One of the reported drivers of HCC is the integration of HBV DNA into the host… read more here.
Keywords: dna integration; integration; dna; hepatitis virus ... See more keywords
Structural Insights on Retroviral DNA Integration: Learning from Foamy Viruses
Sign Up to like & getrecommendations! Published in 2019 at "Viruses"
DOI: 10.3390/v11090770
Abstract: Foamy viruses (FV) are retroviruses belonging to the Spumaretrovirinae subfamily. They are non-pathogenic viruses endemic in several mammalian hosts like non-human primates, felines, bovines, and equines. Retroviral DNA integration is a mandatory step and constitutes… read more here.
Keywords: dna integration; retroviral dna; insights retroviral; integration ... See more keywords