Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs
Sign Up to like & getrecommendations! Published in 2019 at "Electroanalysis"
DOI: 10.1002/elan.201900286
Abstract: The ICN2 is funded by the CERCA programme/Generalitat de Catalunya. ICN2 acknowledges the support of the Spanish MINECO for the Project MAT2017‐87202‐P and through the Severo Ochoa Centers of Excellence Program under Grant SEV2201320295. KDCM… read more here.
Keywords: study dna; based sensors; dna interaction; sensors study ... See more keywords
Dynamics of Dof domain‐DNA interaction in wheat: Insights from atomistic simulations and free energy landscape
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27132
Abstract: DNA‐binding one zinc finger protein (Dof) is a plant‐specific transcription factor involved in numerous biological processes. In the current study, the plausible mechanism underlying Dof domain‐DNA interaction in wheat was investigated using extensive molecular dynamics… read more here.
Keywords: dof domain; domain dna; dna interaction; dna ... See more keywords
Bis-guanylhydrazones as efficient anti-Candida compounds through DNA interaction
Sign Up to like & getrecommendations! Published in 2018 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-018-8749-3
Abstract: Candida spp. are leading causes of opportunistic mycoses, including life-threatening hospital-borne infections, and novel antifungals, preferably aiming targets that have not been used before, are constantly needed. Hydrazone- and guanidine-containing molecules have shown a wide… read more here.
Keywords: dna interaction; bis guanylhydrazones; anti candida;
Transcription Factor-DNA Interaction: From Encode to Biophysics using Evolution and Molecular Dynamic Simulations
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1581
Abstract: Hundreds of millions of dollars have been invested into gene regulation projects such as ENCODE, attempting to decipher the transcriptional regulation network in the human genome to interpret disease mechanisms. However, few labs have found… read more here.
Keywords: evolution; dna; transcription factor; dna interaction ... See more keywords
Synthesis, structure and DNA interaction studies of bisphosphoramides: Theoretical and experimental insights
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.02.017
Abstract: Abstract New bisphosphoramides (having phenyl (EDAPOPh 2 ) and ethoxy (EDADEP) substituents attached to phosphoryl groups bridged with ethylenediamine spacer) are synthesized and structurally characterized by spectroscopic techniques as well as elemental analysis. The molecular… read more here.
Keywords: structure dna; dna; dna interaction; synthesis structure ... See more keywords
Synthesis, characterization, photoluminescence, antiproliferative activity, and DNA interaction of cadmium(II) substituted 4'-phenyl-terpyridine compounds.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111165
Abstract: A series of CdCl2 complexes (1a-1f and 2a-2c) with 4'-(substituted-phenyl)-2,2':6',2″-terpyridine compounds bearing hydrogen (L1a), p-methyl (L1b), p-phenyl (L1c), p-tolyl (L1d), p-carboxyl (L1e), p-fluoro (L1f), p-hydroxyl (L2a), m-hydroxyl (L2b) or o-hydroxyl (L2c), were prepared and characterized… read more here.
Keywords: substituted phenyl; terpyridine compounds; dna interaction; phenyl terpyridine ... See more keywords
Expatiating biological excellence of aminoantipyrine derived novel metal complexes: Combined DNA interaction, antimicrobial, free radical scavenging studies and molecular docking simulations
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.10.021
Abstract: Abstract A novel series of 4-aminoantipyrine derived transition metal complexes were synthesized and characterized by physicochemical methods like elemental analysis, molar conductivity, magnetic susceptibility measurements and multispectral techniques such as FT-IR, UV–Visible, NMR, EPR, ESI-mass… read more here.
Keywords: metal; aminoantipyrine derived; molecular docking; dna interaction ... See more keywords
Dicationic porphyrins bearing thienyl and pyridinium moieties: Synthesis, characterization, DNA interaction and cancer cell toxicity
Sign Up to like & getrecommendations! Published in 2019 at "Polyhedron"
DOI: 10.1016/j.poly.2019.05.042
Abstract: Abstract A new series of trans-dicationic pyridinium porphyrins, 5,15-di(2/3-thienyl)-10,20-bis(3′/4′-N-methylpyridinium)porphyrins (5a–8a), and their copper(II) and zinc(II) derivatives were synthesized in good yield. The compounds were characterized by various spectroscopic methods, together with electrochemical and single crystal… read more here.
Keywords: cell; dicationic porphyrins; dna interaction; pyridinium ... See more keywords
Structural characterization of new zinc(ii) complexes with N2O2 chelating thiosemicarbazidato ligands; investigation of the relationship between their DNA interaction and in vitro antiproliferative activity towards human cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/d0nj02149k
Abstract: Two new zinc(II) complexes were synthesized by condensation of 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione-S-methyl-thiosemicarbazone with salicylaldehyde or 4-methoxy-salicylaldehyde. Structures of the N2O2-chelate complexes, Zn1 and Zn2, were explicated by IR, 1H NMR, ESI-MS and X-ray crystallography. Electronic spectral analysis… read more here.
Keywords: dna; zinc complexes; new zinc; dna interaction ... See more keywords
Abstract LB-119: Targeting DNA-PK via small molecule inhibitors of the Ku-DNA interaction
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-lb-119
Abstract: DNA-PK, the DNA-dependent protein kinase, is a validated target for cancer therapeutics that drives the DNA damage response and plays a critical role in the nonhomologous end joining (NHEJ) DNA repair pathway. Inhibition of DNA-PK… read more here.
Keywords: targeting dna; dna; dna interaction; cancer ... See more keywords
Platinum(II) Terpyridine Anticancer Complexes Possessing Multiple Mode of DNA Interaction and EGFR Inhibiting Activity
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2020.00210
Abstract: Platinum(II) terpyridine complexes has attracted increasing attention as they have displayed great potential as antitumor agents due to their high intercalation affinity with nucleic acids. Epidermal growth factor receptor (EGFR) is often overexpressed in various… read more here.
Keywords: platinum terpyridine; egfr inhibiting; dna interaction; dna ... See more keywords