Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.032
Abstract: DNA interstrand crosslinks (ICLs) that are repaired in non-dividing cells must be recognized independently of replication-associated DNA unwinding. Using cell-free extracts from Xenopus eggs that support neither replication nor transcription, we establish that ICLs are recognized… read more here.
Keywords: interstrand crosslinks; dna interstrand; dna; mismatch repair ... See more keywords
WRNIP1 Is Recruited to DNA Interstrand Crosslinks and Promotes Repair
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DOI: 10.1016/j.celrep.2020.107850
Abstract: Summary The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs). Many FA proteins are recruited to ICLs in a timely fashion so that coordinated repair can occur. However, the mechanism of this process is… read more here.
Keywords: wrnip1; interstrand crosslinks; dna interstrand; fancd2 fanci ... See more keywords
Facile preparation of model DNA interstrand cross-link repair intermediates using ribonucleotide-containing DNA.
Sign Up to like & getrecommendations! Published in 2022 at "DNA repair"
DOI: 10.1016/j.dnarep.2022.103286
Abstract: DNA interstrand cross-links (ICLs) are lesions with a covalent bond formed between DNA strands. ICLs are extremely toxic to cells because they prevent the separation of the two strands, which are necessary for the genetic… read more here.
Keywords: dna; dna interstrand; repair; repair intermediates ... See more keywords
Spatial and Temporal Resolution of the Oxygen-Independent Photoinduced DNA Interstrand Cross-Linking by a Nitroimidazole Derivative
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00460
Abstract: DNA damage is ubiquitous in nature and is at the basis of emergent treatments such as photodynamic therapy, which is based on the activation of highly oxidative reactive oxygen species by photosensitizing O2. However, hypoxia… read more here.
Keywords: dna; oxygen independent; dna damage; dna interstrand ... See more keywords
Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b01135
Abstract: Human exposure to arsenic in drinking water is known to be associated with the development of bladder, lung, kidney, and skin cancers. The molecular mechanisms underlying the carcinogenic effects of arsenic species remain incompletely understood.… read more here.
Keywords: dna interstrand; dna; ring finger; finger domain ... See more keywords
Programmable DNA Interstrand Crosslinking by Alkene-Alkyne [2 + 2] Photocycloaddition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c01611
Abstract: Covalent crosslinking of DNA strands provides a useful tool for medical, biochemical, and DNA nanotechnology applications. Here we present a light-induced interstrand DNA crosslinking reaction using the modified nucleoside 5-phenylethynyl-2'-deoxyuridine (PhedU). The crosslinking ability of… read more here.
Keywords: dna; alkene alkyne; programmable dna; dna interstrand ... See more keywords
The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11050585
Abstract: DNA interstrand cross-links (ICLs) represent a major barrier blocking DNA replication fork progression. ICL accumulation results in growth arrest and cell death—particularly in cell populations undergoing high replicative activity, such as cancer and leukemic cells.… read more here.
Keywords: dna interstrand; dna; fanc brca; interstrand cross ... See more keywords