Digital Polymerase Chain Reaction Paired with High-Speed Atomic Force Microscopy for Quantitation and Length Analysis of DNA Length Polymorphisms.
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DOI: 10.1021/acsnano.0c05897
Abstract: DNA length polymorphisms are found in many serious diseases, and assessment of their length and abundance is often critical for accurate diagnosis. However, measuring their length and frequency in a mostly wild-type background, as occurs… read more here.
Keywords: length; hsafm; microscopy; length polymorphisms ... See more keywords
cGAS is activated by DNA in a length‐dependent manner
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DOI: 10.15252/embr.201744017
Abstract: Cytosolic DNA stimulates innate immune responses, including type I interferons (IFN), which have antiviral and immunomodulatory activities. Cyclic GMP‐AMP synthase (cGAS) recognizes cytoplasmic DNA and signals via STING to induce IFN production. Despite the importance… read more here.
Keywords: cgas; dna; length dependent; dna length ... See more keywords