Temperature adaptation of DNA ligases from psychrophilic organisms
Sign Up to like & getrecommendations! Published in 2019 at "Extremophiles"
DOI: 10.1007/s00792-019-01082-y
Abstract: DNA ligases operating at low temperatures have potential advantages for use in biotechnological applications. For this reason, we have characterized the temperature optima and thermal stabilities of three minimal Lig E-type ATP-dependent DNA ligase originating… read more here.
Keywords: adaptation dna; dna; dna ligases; temperature adaptation ... See more keywords
Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98155-w
Abstract: DNA ligases, the enzymes responsible for joining breaks in the phosphodiester backbone of DNA during replication and repair, vary considerably in size and structure. The smallest members of this enzyme class carry out their functions… read more here.
Keywords: dna; atp dependent; virus; dna ligases ... See more keywords
Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1263
Abstract: Abstract Double-strand DNA breaks (DSBs) are toxic to cells, and improper repair can cause chromosomal abnormalities that initiate and drive cancer progression. DNA ligases III and IV (LIG3, LIG4) have long been credited for repair… read more here.
Keywords: dna; lig1; ligases iii; end joining ... See more keywords
Identification of Novel Inhibitors of Escherichia coli DNA Ligase (LigA)
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26092508
Abstract: Present in all organisms, DNA ligases catalyse the formation of a phosphodiester bond between a 3′ hydroxyl and a 5′ phosphate, a reaction that is essential for maintaining genome integrity during replication and repair. Eubacterial… read more here.
Keywords: ligase liga; escherichia coli; dna; dna ligases ... See more keywords