How DNA loop extrusion mediated by cohesin enables V(D)J recombination.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.11.007
Abstract: 'Structural maintenance of chromosomes' (SMC) complexes are required for the folding of genomic DNA into loops. Theoretical considerations and single-molecule experiments performed with the SMC complexes cohesin and condensin indicate that DNA folding occurs via… read more here.
Keywords: dna loop; extrusion mediated; loop extrusion; dna ... See more keywords
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.10.011
Abstract: The ring-like structural maintenance of chromosomes (SMC) complex MukBEF folds the genome of Escherichia coli and related bacteria into large loops, presumably by active DNA loop extrusion. MukBEF activity within the replication terminus macrodomain is… read more here.
Keywords: structure mukbef; dna; loop entrapment; mukbef ... See more keywords
DNA-loop extruding condensin complexes can traverse one another
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2067-5
Abstract: Condensin, a key component of the structure maintenance of chromosome (SMC) protein complexes, has recently been shown to be a motor that extrudes loops of DNA 1 . It remains unclear, however, how condensin complexes… read more here.
Keywords: loop extruding; dna; condensin; condensin complexes ... See more keywords
Cornelia de Lange syndrome mutations in NIPBL can impair cohesin-mediated DNA loop extrusion
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201029119
Abstract: Cornelia de Lange syndrome (CdLS) is a developmental multisystem disorder frequently associated with mutations in NIPBL. CdLS is thought to arise from developmental gene regulation defects, but how NIPBL mutations cause these is unknown. Here… read more here.
Keywords: mutations nipbl; lange syndrome; dna loop; extrusion ... See more keywords
Genetic diversity of Jiangsu native chicken breeds assessed with the mitochondrial DNA D-loop region
Sign Up to like & getrecommendations! Published in 2018 at "British Poultry Science"
DOI: 10.1080/00071668.2017.1395391
Abstract: ABSTRACT 1. The objective of this study was to determine the origin and evolution of chickens from 5 native breeds that are traditionally raised in Jiangsu Province. 2. To address this question, the complete mitochondrial… read more here.
Keywords: jiangsu; diversity; dna loop; mitochondrial dna ... See more keywords